CHDI
Listed here are over 1,045 publications that describe some of the research funded (in whole or in part) by CHDI Foundation. You can also view just the subset of publications that have CHDI staff as authors.
Publication Search
Title
Journal
Oakeshott S, Balci F, Filippov I, Murphy C, Port R, Connor D, Paintdakhi A, Lesauter J, Menalled L, Ramboz S, Kwak S, Howland D, Silver R, Brunner D
Circadian abnormalities in motor activity in a BAC transgenic mouse model of Huntington`s Disease
Say MJ, Jones R, Scahill RI, Dumas EM, Coleman A, Santos RC, Justo D, Campbell JC, Queller S, Shores EA, Tabrizi SJ, Stout JC, Track-Hd Investigators
Visuomotor integration deficits precede clinical onset in Huntington`s disease
Neuropsychologia
January 1, 2011
49 (2) :264-70
49 (2) :264-70
PMID: 21094653
Nopoulos PC, Aylward EH, Ross CA, Mills JA, Langbehn DR, Johnson HJ, Magnotta VA, Pierson RK, Beglinger LJ, Nance MA, Barker RA, Paulsen JS, Predict-Hd Investigators, Coordinators of the Huntington Study Group
Smaller intracranial volume in prodromal Huntington`s disease: evidence for abnormal neurodevelopment
Stout JC, Paulsen JS, Queller S, Solomon AC, Whitlock KB, Campbell JC, Carlozzi N, Duff K, Beglinger LJ, Langbehn DR, Johnson SA, Biglan KM, Aylward EH
Neurocognitive signs in prodromal Huntington disease
Neuropsychology
January 1, 2011
25 (1) :43844
25 (1) :43844
PMID: 20919768
PMCID: PMC3017660
DOI: 10.1037/a0020937
Nopoulos PC, Aylward EH, Ross CA, Johnson HJ, Magnotta VA, Juhl AR, Pierson RK, Mills J, Langbehn DR, Paulsen JS, Predict-Hd Investigators Coordinators of Huntington Study Group
Cerebral cortex structure in prodromal Huntington disease
Soneson C, Fontes M, Zhou Y, Denisov V, Paulsen JS, Kirik D, Petersen A, Huntington Study Group Predict-HD Investigators
Early changes in the hypothalamic region in prodromal Huntington disease revealed by MRI analysis
Leyva MJ, Degiacomo F, Kaltenbach LS, Holcomb J, Zhang N, Gafni J, Park H, Lo DC, Salvesen GS, Ellerby LM, Ellman JA
Identification and evaluation of small molecule pan-caspase inhibitors in Huntington`s disease models
Paulsen JS, Wang C, Duff K, Barker R, Nance M, Beglinger L, Moser D, Williams JK, Simpson S, Langbehn D, van Kammen DP, Predict-Hd Investigators of the Huntington Study Group
Challenges assessing clinical endpoints in early Huntington disease
Mov Disord
November 15, 2010
25 (15) :2595-603
25 (15) :2595-603
PMID: 20623772
PMCID: PMC2978744
DOI: 10.1002/mds.23337
Graham RK, Deng Y, Carroll J, Vaid K, Cowan C, Pouladi MA, Metzler M, Bissada N, Wang L, Faull RL, Gray M, Yang XW, Raymond LA, Hayden MR
Cleavage at the 586 amino acid caspase-6 site in mutant huntingtin influences caspase-6 activation in vivo
Goodman AO, Morton AJ, Barker RA
Identifying sleep disturbances in Huntington's disease using a simple disease-focused questionnaire
Orth M, Handley OJ, Schwenke C, Dunnett SB, Craufurd D, Ho AK, Wild E, Tabrizi SJ, Landwehrmeyer GB, Investigators of the European Huntington’s Disease Network
Observing Huntington's disease: the European Huntington's Disease Network's REGISTRY
Marrakchi-Kacem L, Delmaire C, Tucholka A, Roca P, Guevara P, Poupon F, Yelnik J, Durr A, Mangin JF, Lehericy S, Poupon C
Analysis of the striato-thalamo-cortical connectivity on the cortical surface to infer biomarkers of Huntington's disease
Med Image Comput Comput Assist
September 20, 2010
13 :217-24
13 :217-24
PMID: 20879318
Perry GM, Tallaksen-Greene S, Kumar A, Heng MY, Kneynsberg A, van Groen T, Detloff PJ, Albin RL, Lesort M
Mitochondrial calcium uptake capacity as a therapeutic target in the R6/2 mouse model of Huntington's disease
Hum Mol Genet
September 1, 2010
19 (17) :3354-71
19 (17) :3354-71
PMID: 20558522
PMCID: 2916705
DOI: 10.1093/hmg/ddq247
Jahanshahi A, Vlamings R, Kaya AH, Lim LW, Janssen ML, Tan S, Visser-Vandewalle V, Steinbusch HW, Temel Y
Hyperdopaminergic status in experimental Huntington disease
J Neuropathol Exp Neurol
September 1, 2010
69 (9) :910-7
69 (9) :910-7
PMID: 20720506
Valenza M, Leoni V, Karasinska JM, Petricca L, Fan J, Carroll J, Pouladi MA, Fossale E, Nguyen HP, Riess O, MacDonald M, Wellington C, DiDonato S, Hayden M, Cattaneo E
Cholesterol defect is marked across multiple rodent models of Huntington's disease and is manifest in astrocytes
Kaltenbach LS, Bolton MM, Shah B, Kanju PM, Lewis GM, Turmel GJ, Whaley JC, Trask OJ Jr, Lo DC
Composite primary neuronal high-content screening assay for Huntington's disease incorporating non-cell-autonomous interactions
Miller JP, Holcomb J, Al-Ramahi I, de Haro M, Gafni J, Zhang N, Kim E, Sanhueza M, Torcassi C, Kwak S, Botas J, Hughes RE, Ellerby LM
Matrix metalloproteinases are modifiers of huntingtin proteolysis and toxicity in Huntington`s disease
Maywood ES, Fraenkel E, McAllister CJ, Wood N, Reddy AB, Hastings MH, Morton AJ
Disruption of peripheral circadian timekeeping in a mouse model of Huntington's disease and its restoration by temporally scheduled feeding
Hobbs NZ, Henley SM, Ridgway GR, Wild EJ, Barker RA, Scahill RI, Barnes J, Fox NC, Tabrizi SJ
The progression of regional atrophy in premanifest and early Huntington's disease: a longitudinal voxel-based morphometry study
J Neurol Neurosurg Psychiatry
July 1, 2010
81 (7) :756-63
81 (7) :756-63
PMID: 19955112
Zuccato C, Valenza M, Cattaneo E
Molecular mechanisms and potential therapeutical targets in Huntington's disease
Rowe KC, Paulsen JS, Langbehn DR, Duff K, Beglinger LJ, Wang C, O’Rourke JJ, Stout JC, Moser DJ
Self-paced timing detects and tracks change in prodromal Huntington disease
Hobbs NZ, Barnes J, Frost C, Henley SM, Wild EJ, Macdonald K, Barker RA, Scahill RI, Fox NC, Tabrizi SJ
Onset and progression of pathologic atrophy in Huntington disease: a longitudinal MR imaging study
Schaertl S, Prime M, Wityak J, Dominguez C, Munoz-Sanjuan I, Pacifici RE, Courtney S, Scheel A, Macdonald D
A profiling platform for the characterization of transglutaminase 2 (TG2) inhibitors
Paulsen JS, Nopoulos PC, Aylward E, Ross CA, Johnson H, Magnotta VA, Juhl A, Pierson RK, Mills J, Langbehn D, Nance M, Predict-Hd Investigators, Coordinators of the Huntington`s Study Group
Striatal and white matter predictors of estimated diagnosis for Huntington disease
Crittenden JR, Dunn DE, Merali FI, Woodman B, Yim M, Borkowska AE, Frosch MP, Bates GP, Housman DE, Lo DC, Graybiel AM
CalDAG-GEFI down-regulation in the striatum as a neuroprotective change in Huntington's disease
Becanovic K, Pouladi MA, Lim RS, Kuhn A, Pavlidis P, Luthi-Carter R, Hayden MR, Leavitt BR
Transcriptional changes in Huntington disease identified using genome-wide expression profiling and cross-platform analysis
Stoffers D, Sheldon S, Kuperman JM, Goldstein J, Corey-Bloom J, Aron AR
Contrasting gray and white matter changes in preclinical Huntington disease: an MRI study
Menalled LB, Patry M, Ragland N, Lowden PA, Goodman J, Minnich J, Zahasky B, Park L, Leeds J, Howland D, Signer E, Tobin AJ, Brunner D
Comprehensive behavioral testing in the R6/2 mouse model of Huntington's disease shows no benefit from CoQ10 or minocycline
Langbehn DR, Hayden MR, Paulsen JS, Predict-Hd Investigators of the Huntington Study Group
CAG-repeat length and the age of onset in Huntington disease (HD): a review and validation study of statistical approaches
Am J Med Genet B Neuropsychiatr Genet
March 5, 2010
153B (2) :397-408
153B (2) :397-408
PMID: 19548255
PMCID: PMC3048807
DOI: 10.1002/ajmg.b.30992
Wood NI, Carta V, Milde S, Skillings EA, McAllister CJ, Ang YL, Duguid A, Wijesuriya N, Afzal SM, Fernandes JX, Leong TW, Morton AJ
Responses to environmental enrichment differ with sex and genotype in a transgenic mouse model of Huntington's disease
Yerkes S, Vesenka J, Kmiec EB
A stable G-quartet binds to a huntingtin protein fragment containing expanded polyglutamine tracks
Paulsen JS
Early detection of Huntington disease
Bechtel N, Scahill RI, Rosas HD, Acharya T, van den Bogaard SJ, Jauffret C, Say MJ, Sturrock A, Johnson H, Onorato CE, Salat DH, Durr A, Leavitt BR, Roos RA, Landwehrmeyer GB, Langbehn DR, Stout JC, Tabrizi SJ, Reilmann R
Tapping linked to function and structure in premanifest and symptomatic Huntington disease
Sturrock A, Laule C, Decolongon J, Dar Santos R, Coleman AJ, Creighton S, Bechtel N, Reilmann R, Hayden MR, Tabrizi SJ, Mackay AL, Leavitt BR
Magnetic resonance spectroscopy biomarkers in premanifest and early Huntington disease
Duff K, Paulsen J, Mills J, Beglinger LJ, Moser DJ, Smith MM, Langbehn D, Stout J, Queller S, Harrington DL, PREDICT-HD Investigators and Coordinators of the Huntington Study Group
Mild cognitive impairment in prediagnosed Huntington disease
Duff K, Paulsen JS, Beglinger LJ, Langbehn DR, Wang C, Stout JC, Ross CA, Aylward E, Carlozzi NE, Queller S, Predict-HD Investigators of the Huntington Study Group
"Frontal" behaviors before the diagnosis of Huntington`s disease and their relationship to markers of disease progression: evidence of early lack of awareness
Bradford J, Shin JY, Roberts M, Wang CE, Li XJ, Li S
Expression of mutant huntingtin in mouse brain astrocytes causes age-dependent neurological symptoms
Thompson LM, Aiken CT, Kaltenbach LS, Agrawal N, Illes K, Khoshnan A, Martinez-Vincente M, Arrasate M, O’Rourke JG, Khashwji H, Lukacsovich T, Zhu YZ, Lau AL, Massey A, Hayden MR, Zeitlin SO, Finkbeiner S, Green KN, LaFerla FM, Bates G, Huang L, Patterson PH, Lo DC, Cuervo AM, Marsh JL, Steffan JS
IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome
Gu X, Greiner ER, Mishra R, Kodali R, Osmand A, Finkbeiner S, Steffan JS, Thompson LM, Wetzel R, Yang XW
Serines 13 and 16 are critical determinants of full-length human mutant huntingtin induced disease pathogenesis in HD mice