CHDI
Listed here are over 950 publications that describe some of the research funded (in whole or in part) by CHDI Foundation. You can also view just the subset of publications that have CHDI staff as authors.
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Title
Journal
Duff K, Paulsen J, Mills J, Beglinger LJ, Moser DJ, Smith MM, Langbehn D, Stout J, Queller S, Harrington DL, PREDICT-HD Investigators and Coordinators of the Huntington Study Group
Mild cognitive impairment in prediagnosed Huntington disease
Duff K, Paulsen JS, Beglinger LJ, Langbehn DR, Wang C, Stout JC, Ross CA, Aylward E, Carlozzi NE, Queller S, Predict-HD Investigators of the Huntington Study Group
"Frontal" behaviors before the diagnosis of Huntington`s disease and their relationship to markers of disease progression: evidence of early lack of awareness
Bradford J, Shin JY, Roberts M, Wang CE, Li XJ, Li S
Expression of mutant huntingtin in mouse brain astrocytes causes age-dependent neurological symptoms
Thompson LM, Aiken CT, Kaltenbach LS, Agrawal N, Illes K, Khoshnan A, Martinez-Vincente M, Arrasate M, O’Rourke JG, Khashwji H, Lukacsovich T, Zhu YZ, Lau AL, Massey A, Hayden MR, Zeitlin SO, Finkbeiner S, Green KN, LaFerla FM, Bates G, Huang L, Patterson PH, Lo DC, Cuervo AM, Marsh JL, Steffan JS
IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome
Gu X, Greiner ER, Mishra R, Kodali R, Osmand A, Finkbeiner S, Steffan JS, Thompson LM, Wetzel R, Yang XW
Serines 13 and 16 are critical determinants of full-length human mutant huntingtin induced disease pathogenesis in HD mice
Moffitt H, McPhail GD, Woodman B, Hobbs C, Bates GP
Formation of polyglutamine inclusions in a wide range of non-CNS tissues in the HdhQ150 knock-in mouse model of Huntington's disease
Li X, Standley C, Sapp E, Valencia A, Qin ZH, Kegel KB, Yoder J, Comer-Tierney LA, Esteves M, Chase K, Alexander J, Masso N, Sobin L, Bellve K, Tuft R, Lifshitz L, Fogarty K, Aronin N, DiFiglia M
Mutant huntingtin impairs vesicle formation from recycling endosomes by interfering with Rab11 activity
Mol Cell Biol
November 1, 2009
29 (22) :6106-16
29 (22) :6106-16
PMID: 19752198
PMCID: 2772576
DOI: 10.1128/MCB.00420-09
Ciamei A, Morton AJ
Progressive imbalance in the interaction between spatial and procedural memory systems in the R6/2 mouse model of Huntington's disease
Hobbs NZ, Henley SM, Wild EJ, Leung KK, Frost C, Barker RA, Scahill RI, Barnes J, Tabrizi SJ, Fox NC
Automated quantification of caudate atrophy by local registration of serial MRI: evaluation and application in Huntington's disease
Biglan KM, Ross CA, Langbehn DR, Aylward EH, Stout JC, Queller S, Carlozzi NE, Duff K, Beglinger LJ, Paulsen JS, Predict-Hd Investigators of the Huntington Study Group
Motor abnormalities in premanifest persons with Huntington`s disease: the PREDICT-HD study
Mov Disord
September 15, 2009
24 (12) :1763-72
24 (12) :1763-72
PMID: 19562761
PMCID: PMC3048804
DOI: 10.1002/mds.22601
Tabrizi SJ, Langbehn DR, Leavitt BR, Roos RAC, Durr A, Craufurd D, Kennard C, Hicks SL, Fox NC, Scahill RI, Borowsky B, Tobin A J, Rosas HD, Johnson H, Reilmann R, Landwehrmeyer B, Stout JC
Biological and clinical manifestations of Huntington`s disease in the longitudinal TRACK-HD study: cross-sectional analysis of baseline data
Menalled L, El-Khodor BF, Patry M, Suarez-Farinas M, Orenstein SJ, Zahasky B, Leahy C, Wheeler V, Yang XW, MacDonald M, Morton AJ, Bates G, Leeds J, Park L, Howland D, Signer E, Tobin A, Brunner D
Systematic behavioral evaluation of Huntington`s disease transgenic and knock-in mouse models
Silvestroni A, Faull RL, Strand AD, Möller T
Distinct neuroinflammatory profile in post-mortem human Huntington's disease
Pallier PN, Morton AJ
Management of sleep/wake cycles improves cognitive function in a transgenic mouse model of Huntington's disease
Zuccato C, Cattaneo E
Brain-derived neurotrophic factor in neurodegenerative diseases
Liu Y, Lacson R, Cassaday J, Ross DA, Kreamer A, Hudak E, Peltier R, McLaren D, Munoz-Sanjuan I, Santini F, Strulovici B, Ferrer M
Identification of small-molecule modulators of mouse SVZ progenitor cell proliferation and differentiation through high-throughput screening
Weaver KE, Richards TL, Liang O, Laurino MY, Samii A, Aylward EH
Longitudinal diffusion tensor imaging in Huntington`s Disease
Pallier PN, Drew CJ, Morton AJ
The detection and measurement of locomotor deficits in a transgenic mouse model of Huntington's disease are task- and protocol-dependent: influence of non-motor factors on locomotor function
Morton AJ, Glynn D, Leavens W, Zheng Z, Faull RL, Skepper JN, Wight JM
Paradoxical delay in the onset of disease caused by super-long CAG repeat expansions in R6/2 mice
Joshi PR, Wu NP, André VM, Cummings DM, Cepeda C, Joyce JA, Carroll JB, Leavitt BR, Hayden MR, Levine MS, Bamford NS
Age-dependent alterations of corticostriatal activity in the YAC128 mouse model of Huntington disease
Sawiak SJ, Wood NI, Williams GB, Morton AJ, Carpenter TA
Use of magnetic resonance imaging for anatomical phenotyping of the R6/2 mouse model of Huntington's diseas
Munoz-Sanjuan, I
Glial progenitor cell transplantation and the generation of chimeric animal models with human brain cells: implications for novel therapeutics
Expert Opin Ther Pat
January 1, 2009
19 (12) :1639-46
19 (12) :1639-46
PMID: 19939186
Kloppel S, Chu C, Tan GC, Draganski B, Johnson H, Paulsen JS, Kienzle W, Tabrizi SJ, Ashburner J, Frackowiak RS, PREDICT-HD Investigators of the Huntington Study Group
Automatic detection of preclinical neurodegeneration: presymptomatic Huntington disease
Southwell AL, Khoshnan A, Dunn DE, Bugg CW, Lo DC, Patterson PH
Intrabodies binding the proline-rich domains of mutant huntingtin increase its turnover and reduce neurotoxicity
Colin E, Zala D, Liot G, Rangone H, Borrell-Pagès M, Li XJ, Saudou F, Humbert S
Huntingtin phosphorylation acts as a molecular switch for anterograde retrograde transport in neurons
Warby SC, Doty CN, Graham RK, Carroll JB, Yang YZ, Singaraja RR, Overall CM, Hayden MR
Activated caspase-6 and caspase-6-cleaved fragments of huntingtin specifically colocalize in the nucleus
Cho SJ, Sun Y
Visual exploration of structure-activity relationship using maximum common framework
Paulsen JS, Langbehn DR, Stout JC, Aylward E, Ross CA, Nance M, Guttman M, Johnson S, MacDonald M, Beglinger LJ, Duff K, Kayson E, Biglan K, Shoulson I, Oakes D, Hayden M, Predict-HD Investigators, Coordinators of the Huntington Study Group
Detection of Huntington`s disease decades before diagnosis: the Predict-HD study
Henley SM, Wild EJ, Hobbs NZ, Warren JD, Frost C, Scahill RI, Ridgway GR, MacManus DG, Barker RA, Fox NC, Tabrizi SJ
Defective emotion recognition in early HD is neuropsychologically and anatomically generic
Neuropsychologia
July 1, 2008
46 (8) :2152-60
46 (8) :2152-60
PMID: 18407301
Lerch JP, Carroll JB, Dorr A, Spring S, Evans AC, Hayden MR, Sled JG, Henkelman RM
Cortical thickness measured from MRI in the YAC128 mouse model of Huntington's disease
Ciamei A, Morton AJ
Rigidity in social and emotional memory in the R6/2 mouse model of Huntington`s disease
Lerch JP, Carroll JB, Spring S, Bertram LN, Schwab C, Hayden MR, Henkelman RM
Automated deformation analysis in the YAC128 Huntington disease mouse model
Beglinger LJ, Paulsen JS, Watson DB, Wang C, Duff K, Langbehn DR, Moser DJ, Paulson HL, Aylward EH, Carlozzi NE, Queller S, Stout JC
Obsessive and compulsive symptoms in prediagnosed Huntington`s disease
J Clin Psychiatry
January 1, 2008
69 (11) :1758-65
69 (11) :1758-65
PMID: 19012814
Duff K, Paulsen JS, Beglinger LJ, Langbehn DR, Stout JC, Predict-HD Investigators of the Huntington Study Group
Psychiatric symptoms in Huntington`s disease before diagnosis: the predict-HD study
Biol Psychiatry
December 15, 2007
62 (12) :1341-6
62 (12) :1341-6
PMID: 17481592
DiFiglia M, Sena-Esteves M, Chase K, Sapp E, Pfister E, Sass M, Yoder J, Reeves P, Pandey RK, Rajeev KG, Manoharan M, Sah DW, Zamore PD, Aronin N
Therapeutic silencing of mutant huntingtin with siRNA attenuates striatal and cortical neuropathology and behavioral deficits
Heng MY, Tallaksen-Greene SJ, Detloff PJ, Albin RL
Longitudinal evaluation of the Hdh(CAG)150 knock-in murine model of Huntington's disease
Anne SL, Saudou F, Humbert S
Phosphorylation of huntingtin by cyclin-dependent kinase 5 is induced by DNA damage and regulates wild-type and mutant huntingtin toxicity in neurons
Dalrymple A, Wild EJ, Joubert R, Sathasivam K, Björkqvist M, Petersén A, Jackson GS, Isaacs JD, Kristiansen M, Bates GP, Leavitt BR, Keir G, Ward M, Tabrizi SJ
Proteomic profiling of plasma in Huntington's disease reveals neuroinflammatory activation and biomarker candidates
Johnson SA, Stout JC, Solomon AC, Langbehn DR, Aylward EH, Cruce CB, Ross CA, Nance M, Kayson E, Julian-Baros E, Hayden MR, Kieburtz K, Guttman M, Oakes D, Shoulson I, Beglinger L, Duff K, Penziner E, Paulsen JS, Predict-HD Investigators of the Huntington Study Group
Beyond disgust: impaired recognition of negative emotions prior to diagnosis in Huntington`s disease
Kung VW, Hassam R, Morton AJ, Jones S
Dopamine-dependent long term potentiation in the dorsal striatum is reduced in the R6/2 mouse model of Huntington's disease