CHDI
2020
Authors
Title
Journal
- Smith-Geater C, | Hernandez SJ, | Lim RG, | Adam M, | Wu J, | Stocksdale JT, | Wassie BT, | Gold MP, | Wang KQ, | Miramontes R, | Kopan L, | Orellana I, | Joy S, | Kemp PJ, | Allen ND, | Fraenkel E, | Thompson LM |Aberrant development corrected in adult-onset Huntington's disease iPSC-derived neuronal cultures via WNT signaling modulationStem Cell Reports406-41914(3):20200310PMID:32109367PMCID: 7066322Mégret L, | Nair SS, | Dancourt J, | Aaronson J, | Rosinski J, | Neri C |Combining feature selection and shape analysis uncovers precise rules for miRNA regulation in Huntington's disease miceBMC Bioinformatics7521(1):20200224PMID:32093602Ghavami A, | Olsen M, | Kwan M, | Beltran J, | Shea J, | Ramboz S, | Duan W, | Lavery D, | Howland D, | Park LC |Transcriptional assessment of striatal mRNAs as valid biomarkers of disease progression in three mouse models of Huntington's diseaseJ Huntingtons Dis13-319(1):20200210PMID:32007959DOI: 10.3233/JHD-190389Alexander B, | Georgiou-Karistianis N, | Beare R, | Ahveninen LM, | Lorenzetti V, | Stout JC, | Glikmann-Johnston Y |Accuracy of automated amygdala MRI segmentation approaches in Huntington's disease in the IMAGE-HD cohortHum Brain Mapp():20200207PMID:32034838DOI: 10.1002/hbm.24918Messer A, | Butler DC |Optimizing intracellular antibodies (intrabodies/nanobodies) to treat neurodegenerative disordersNeurobiol Dis104619134():20200203PMID:31669671McAdam RL, | Morton A, | Gordon SL, | Alterman JF, | Khvorova A, | Cousin MA, | Smillie KJ |Loss of huntingtin function slows synaptic vesicle endocytosis in striatal neurons from the htt (Q140/Q140) mouse model of Huntington's diseaseNeurobiol Dis104637134():20200203PMID:31614197Batista AR, | King OD, | Reardon CP, | Davis C, | Shankaracharya, | Philip V, | Gray-Edwards H, | Aronin N, | Lutz C, | Landers J, | Sena-Esteves M |Ly6a differential expression in blood-brain barrier is responsible for strain specific central nervous system transduction profile of AAV-PHP.B.Hum Gene Ther90-10231(1-2):20200130PMID:31696742DOI: 10.1089/hum.2019.186Polosecki P, | Castro E, | Rish I, | Pustina D, | Warner JH, | Wood A, | Sampaio C, | Cecchi GA |Resting-state connectivity stratifies premanifest Huntington's disease by longitudinal cognitive decline rateSci Rep125210(1):20200127PMID:31988371Fazio P, | Fitzer-Attas CJ, | Mrzljak L, | Bronzova J, | Nag S, | Warner JH, | Landwehrmeyer B, | Al-Tawil N, | Halldin C, | Forsberg A, | Ware J, | Dilda V, | Wood A, | Sampaio C, | Varrone A, | PEARL-HD and LONGPDE10 collaborators |PET molecular imaging of phosphodiesterase 10A: An early biomarker of Huntington's disease progressionMov Disord():20200122PMID:31967355DOI: 10.1002/mds.27963Kedaigle AJ, | Reidling JC, | Lim RG, | Adam M, | Wu J, | Wassie B, | Stocksdale JT, | Casale MS, | Fraenkel E, | Thompson LM |Treatment with JQ1, a BET bromodomain inhibitor, is selectively detrimental to R6/2 Huntington's disease miceHum Mol Genet202-21529(2):20200120PMID:31696228DOI: 10.1093/hmg/ddz264Chongtham A, | Bornemann DJ, | Barbaro BA, | Lukacsovich T, | Agrawal N, | Syed A, | Worthge S, | Purcell J, | Burke J, | Chin TM, | Marsh JL |Effects of flanking sequences and cellular context on subcellular behavior and pathology of mutant HTTHum Mol Genet():20200116PMID:31943010DOI: 10.1093/hmg/ddaa001Julayanont P, | McFarland NR, | Heilman KM |Mild cognitive impairment and dementia in motor manifest Huntington's disease: Classification and prevalenceJ Neurol Sci116523408():20200115PMID:31678902Cariulo C, | Verani M, | Martufi P, | Ingenito R, | Finotto M, | Deguire SM, | Lavery DJ, | Toledo-Sherman L, | Lee R, | Doherty EM, | Vogt TF, | Dominguez C, | Lashuel HA, | Petricca L, | Caricasole A |Ultrasensitive quantitative measurement of huntingtin phosphorylation at residue S13Biochem Biophys Res Commun549-554521(3):20200115PMID:31677786Bertoglio D, | Verhaeghe J, | Korat Š, | Miranda A, | Cybulska K, | Wyffels L, | Stroobants S, | Mrzljak L, | Dominguez C, | Skinbjerg M, | Liu L, | Munoz-Sanjuan I, | Staelens S |Elevated type 1 metabotropic glutamate receptor availability in a mouse model of Huntington's disease: a longitudinal PET studyMol Neurobiol():20200110PMID:31912442Pflanz CP, | Charquero-Ballester M, | Majid DSA, | Winkler AM, | Vallée E, | Aron AR, | Jenkinson M, | Douaud G |One-year changes in brain microstructure differentiate preclinical Huntington's disease stagesNeuroimage Clin10209925():20200106PMID:31865023
2019
AuthorsTitleJournal- Aviolat H, | Pinto RM, | Godschall E, | Murtha R, | Richey HE, | Sapp E, | Vodicka P, | Wheeler VC, | Kegel-Gleason KB, | DiFiglia M |Assessing average somatic CAG repeat instability at the protein levelSci Rep191529(1):20191216PMID:31844074Chandra A, | Valkimadi PE, | Pagano G, | Cousins O, | Dervenoulas G, | Politis M, | Alzheimer's Disease Neuroimaging Initiative |Applications of amyloid, tau, and neuroinflammation PET imaging to Alzheimer's disease and mild cognitive impairmentHum Brain Mapp5424-544240(18):20191215PMID:31520513DOI: 10.1002/hbm.24782Ardan T, | Baxa M, | Levinská B, | Sedláčková M, | Nguyen TD, | Klíma J, | Juhás Š, | Juhásová J, | Šmatlíková P, | Vochozková P, | Motlík J, | Ellederová Z |Transgenic minipig model of Huntington's disease exhibiting gradually progressing neurodegenerationDis Model Mechdmm04131913(2):20191212PMID:31645369DOI: 10.1242/dmm.041319PMCID: 6918760Bertoglio D, | Verhaeghe J, | Korat Š, | Miranda A, | Wyffels L, | Stroobants S, | Mrzljak L, | Dominguez C, | Liu L, | Skinbjerg M, | Munoz-Sanjuan I, | Staelens S |In vitro and In vivo assessment of suitable reference region and kinetic modelling for the mGluR1 radioligand [(11)C] ITDM in miceMol Imaging Biol():20191202PMID:31792838Estrada-Sánchez AM, | Blake CL, | Barton SJ, | Howe AG, | Rebec GV |Lack of mutant huntingtin in cortical efferents improves behavioral inflexibility and corticostriatal dynamics in Huntington's disease miceJ Neurophysiol2621-2629122(6):20191202PMID:31693428PMCID: 6966319Smarr B, | Cutler T, | Loh DH, | Kudo T, | Kuljis D, | Kriegsfeld L, | Ghiani CA, | Colwell CS |Circadian dysfunction in the Q175 model of Huntington's disease: Network analysisJ Neurosci Res1606-162397(12):20191202PMID:31359503DOI: 10.1002/jnr.24505Papadopoulou AS, | Gomez-Paredes C, | Mason MA, | Taxy BA, | Howland D, | Bates GP |Extensive expression analysis of Htt transcripts in brain regions from the zQ175 HD mouse model using a QuantiGene multiplex assaySci Rep161379(1):20191106PMID:31695145Irvine EE, | Katsouri L, | Plattner F, | Al-Qassab H, | Al-Nackkash R, | Bates GP, | Withers DJ |Genetic deletion of S6k1 does not rescue the phenotypic deficits observed in the R6/2 mouse model of Huntington's diseaseSci Rep161339(1):20191106PMID:31695068PMCID: 6834565Marottoli FM, | Priego M, | Flores-Barrera E, | Pisharody R, | Zaldua S, | Fan KD, | Ekkurthi GK, | Brady ST, | Morfini GA, | Tseng KY, | Tai LM |EGF treatment improves motor behavior and cortical GABAergic function in the R6/2 mouse model of Huntington's diseaseMol Neurobiol7708-771856(11):20191105PMID:31104296PMCID: 6815691Gregory S, | Odish OFF, | Mayer I, | Mills J, | Johnson EB, | Scahill RI, | Rothwell J, | Rees G, | Long JD, | Tabrizi SJ, | Roos RAC, | Orth M |Multimodal characterization of the visual network in Huntington's disease gene carriersClin Neurophysiol2053-2059130(11):20191101PMID:31541982Ciosi M, | Maxwell A, | Cumming SA, | Hensman Moss DJ, | Alshammari AM, | Flower MD, | Durr A, | Leavitt BR, | Roos RAC, | TRACK-HD team, | Enroll-HD team | Holmans P, | Jones L, | Langbehn DR, | Kwak S, | Tabrizi SJ, | Monckton DG |A genetic association study of glutamine-encoding DNA sequence structures, somatic CAG expansion, and DNA repair gene variants, with Huntington disease clinical outcomesEBioMedicine568-58048():20191030PMID:31607598Diaz-Castro B, | Gangwani MR, | Yu X, | Coppola G, | Khakh BS |Astrocyte molecular signatures in Huntington's diseaseSci Transl Medeaaw854611(514):20191016PMID:31619545Haremaki T, | Metzger JJ, | Rito T, | Ozair MZ, | Etoc F, | Brivanlou AH |Self-organizing neuruloids model developmental aspects of Huntington's disease in the ectodermal compartmentNat Biotechnol1198-120837(10):20191011PMID:31501559Kim KH, | Abu Elneel K, | Shin JW, | Keum JW, | Seong D, | Kwak S, | Lee R, | Gusella JF, | MacDonald ME, | Seong IS, | Lee JM |Full sequence of mutant huntingtin 3'-untranslated region and modulation of its gene regulatory 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MultiomicsMol Cell ProteomicsS92-S11318(8):20190809PMID:31040226GeM-HD Consortium, | Lee JM, | Correia K, | Loupe J, | Kim KH, | Barker D, | Hong EP, | Chao MJ, | Long JD, | Lucente D, | Vonsattel JPG, | Pinto RM, | Abu Elneel K, | Ramos EM, | Mysore JS, | Gillis T, | Wheeler VC, | MacDonald ME, | Gusella JF, | McAllister B, | Massey T, | Medway C, | Stone TC, | Hall L, | Jones L, | Holmans P, | Kwak S, | Ehrhardt AG, | Sampaio C, | Ciosi M, | Maxwell A, | Chatzi A, | Monckton DG, | Orth M, | Landwehrmeyer GB, | Paulsen JS, | Dorsey ER, | Shoulson I, | Myers RH |CAG repeat not polyglutamine length determines timing of Huntington's disease onsetCell887-900178(4):20190808PMID:31398342PMCID: 6700281Huhtala T, | Poutiainen P, | Rytkönen J, | Lehtimäki K, | Parkkari T, | Kasanen I, | Airaksinen AJ, | Koivula T, | Sweeney P, | Kontkanen O, | Wityak J, | Dominiquez C, | Park LC |Improved synthesis of [(18)F] fallypride and characterization of a Huntington's disease mouse model, zQ175DN KI, 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diseaseBrain2432-2450142(8):20190801PMID:31286142DOI: 10.1093/brain/awz174Bertoglio D, | Verhaeghe J, | Miranda A, | Kertesz I, | Cybulska K, | Korat Š, | Wyffels L, | Stroobants S, | Mrzljak L, | Dominguez C, | Liu L, | Skinbjerg M, | Munoz-Sanjuan I, | Staelens S |Validation and noninvasive kinetic modeling of [(11) C] UCB-J PET imaging in miceJ Cereb Blood Flow Metab():20190731PMID:31307287Flower M, | Lomeikaite V, | Ciosi M, | Cumming S, | Morales F, | Lo K, | Hensman Moss D, | Jones L, | Holmans P, | TRACK-HD Investigators, | OPTIMISTIC Consortium, | Monckton DG, | Tabrizi SJ |MSH3 modifies somatic instability and disease severity in Huntington's and myotonic dystrophy type 1Brain1876–1886142(7):20190715PMID:31216018DOI: 10.1093/brain/awz115PMCID: 6598626Wilkes FA, | Abaryan Z, | Ching CRK, | Gutman BA, | Madsen SK, | Walterfang M, | Velakoulis D, | Stout JC, | Chua P, | Egan GF, | Thompson PM, | Looi JCL, | Georgiou-Karistianis N |Striatal morphology and neurocognitive 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| IPMDS Rating Scales Review Committee |Scales to assess impulsive and compulsive behaviors in Parkinson's disease: Critique and recommendationsMov Disord791-79834(6):20190603PMID:31136681DOI: 10.1002/mds.27689Huguet G, | Temel Y, | Kádár E, | Pol S, | Casaca-Carreira J, | Segura-Torres P, | Jahanshahi A |Altered expression of dopaminergic cell fate regulating genes prior to manifestation of symptoms in a transgenic rat model of Huntington's diseaseBrain Res101-1081712():20190601PMID:30711400Ochaba J, | Fote G, | Kachemov M, | Thein S, | Yeung SY, | Lau AL, | Hernandez S, | Lim RG, | Casale M, | Neel MJ, | Monuki ES, | Reidling J, | Housman DE, | Thompson LM, | Steffan JS |IKKβ slows Huntington's disease progression in R6/1 miceProc Natl Acad Sci USA10952-10961116(22):20190528PMID:31088970Octeau JC, | Gangwani MR, | Allam SL, | Tran D, | Huang S, | Hoang-Trong TM, | Golshani P, | Rumbell TH, | Kozloski JR, | Khakh BS |Transient, consequential increases in extracellular potassium ions 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6527892Sharma M, | Subramaniam S |Rhes travels from cell to cell and transports Huntington disease protein via TNT-like protrusionJ Cell Biolpii: jcb.201807068():20190510PMID:31076452Pido-Lopez J, | Tanudjojo B, | Farag S, | Bondulich MK, | Andre R, | Tabrizi SJ, | Bates GP |Inhibition of tumour necrosis factor alpha in the R6/2 mouse model of Huntington's disease by etanercept treatmentSci Rep72029(1):20190510PMID:31076648PMCID: 6510744Shahn Z, | Li Y, | Sun Z, | Mohan A, | Sampaio C, | Hu J |G-Computation and hierarchical models for estimating multiple causal effects from observational disease registries with irregular visitsAMIA Jt Summits Transl Sci Proc789-7982019():20190506PMID:31259036PMCID: 6568089Di Marco A, | Gonzalez Paz O, | Fini I, | Vignone D, | Cellucci A, | Battista MR, | Auciello G, | Orsatti L, | Zini M, | Monteagudo E, | Khetarpal V, | Rose M, | Dominguez C, | Herbst T, | Toledo-Sherman L, | Summa V, | Muñoz-Sanjuán I |Application of an in vitro blood-brain barrier model in the selection of experimental drug candidates for the treatment of Huntington's diseaseMol Pharm2069-208216(5):20190506PMID:30916978Shoulson I, | Eberly S, | Oakes D, | Kayson E, | Young AB | PHAROS Investigators |Phenotype-genotype discrepancies in the prospective Huntington at-risk observational studyAnn Clin Transl Neurol1046-10526(6):20190503PMID:31211168DOI: 10.1002/acn3.781PMCID: 6562068Vizcarra JA, | Sánchez-Ferro Á, | Maetzler W, | Marsili L, | Zavala L, | Lang AE, | Martinez-Martin P, | Mestre TA, | Reilmann R, | Hausdorff JM, | Dorsey ER, | Paul SS, | Dexheimer JW, | Wissel BD, | Fuller RLM, | Bonato P, | Tan AH, | Bloem BR, | Kopil C, | Daeschler M, | Bataille L, | Kleiner G, | Cedarbaum JM, | Klucken J, | Merola A, | Goetz CG, | Stebbins GT, | Espay AJ | MDS Technology Task Force and | MDS Rating Scales Program Electronic Development Ad-Hoc Committee |The Parkinson's disease e-diary: Developing a clinical and research tool for the digital ageMov Disord676-68134(5):20190501PMID:30901492DOI: 10.1002/mds.27673Kojer K, | Hering T, | Bazenet C, | Weiss A, | Herrmann F, | Taanman JW, | Orth M |Huntingtin aggregates and mitochondrial pathology in skeletal muscle but not heart of late-stage R6/2 miceJ Huntingtons Dis145–1598(2):20190430PMID:30814364DOI: 10.3233/JHD-180324Harding RJ, | Loppnau P, | Ackloo S, | Lemak A, | Hutchinson A, | Hunt B, | Holehouse AS, | Ho JC, | Fan L, | Toledo-Sherman L, | Seitova A, | Arrowsmith CH |Design and characterization of mutant and wildtype huntingtin proteins produced from a toolkit of scalable eukaryotic expression systemsJ Biol Chem6986-7001294(17):20190426PMID:30842263Carrillo-Reid L, | Day M, | Xie Z, | Melendez AE, | Kondapalli J, | Plotkin JL, | Wokosin DL, | Chen Y, | Kress GJ, | Kaplitt M, | Ilijic E, | Guzman JN, | Chan SS, | Surmeier DJ |Mutant huntingtin enhances activation of dendritic Kv4 K(+) channels in striatal spiny projection neuronsElifee408188():20190424PMID:31017573DOI: 10.7554/eLife.40818Espinoza FA, | Liu J, | Ciarochi J, | Turner JA, | Vergara VM, | Caprihan A, | Misiura M, | Johnson HJ, | Long JD, | Bockholt JH, | Paulsen JS, | Calhoun VD |Dynamic functional network connectivity in Huntington's disease and its associations with motor and cognitive measuresHum Brain Mapp1955-196840(6):20190415PMID:30618191DOI: 10.1002/hbm.24504Todorov DI, | Capps RA, | Barnett WH, | Latash EM, | Kim T, | Hamade KC, | Markin SN, | Rybak IA, | Molkov YI |The interplay between cerebellum and basal ganglia in motor adaptation: A modeling studyPLoS Onee021492614(4):20190412PMID:30978216PMCID: 6461234Tang X, | Ross CA, | Johnson H, | Paulsen JS, | Younes L, | Albin RL, | Ratnanather JT, | Miller MI |Regional subcortical shape analysis in premanifest Huntington's diseaseHum Brain Mapp1419-143340(5):20190401PMID:30376191DOI: 10.1002/hbm.24456Toledo-Sherman L, | Breccia P, | Cachope R, | Bate JR, | Angulo-Herrera I, | Wishart G, | Matthews KL, | Martin SL, | Cox HC, | 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