Scientific Publications

Listed here are over 700 publications that describe some of the research funded (in whole or in part) by CHDI Foundation. You can also view just the subset of publications that have CHDI staff as authors.

Publication Search

Authors

Title

Journal

Zhang N, Bailus BJ, Ring KL, Ellerby LM
iPSC-based drug screening for Huntington's disease
Brain Res
May 1, 2016
1638 :42-56
PMID: 26428226
PMCID: PMC4814369
Choudhury SR, Harris AF, Cabral DJ, Keeler AM, Sapp E, Ferreira JS, Gray-Edwards HL, Johnson JA, Johnson AK, Su Q, Stoica L, DiFiglia M, Aronin N, Martin DR, Gao G, Sena-Esteves M
Widespread central nervous system gene transfer and silencing after systemic delivery of novel AAV-AS vector
Mol Ther
April 29, 2016
24 (4) :726-35
PMID: 26708003
PMCID: PMC4886933
Kumar A, Zhang J, Tallaksen-Greene S, Crowley MR, Crossman DK, Morton AJ, Van Groen T, Kadish I, Albin RL, Lesort M, Detloff PJ
Allelic series of Huntington`s disease knock-in mice reveals expression discorrelates
Hum Mol Genet
April 15, 2016
25 (8) :1619-36
PMID: 26908599
PMCID: PMC4805312
Langfelder P, Cantle JP, Chatzopoulou D, Wang N, Gao F, Al-Ramahi I, Lu XH, Ramos EM, El-Zein K, Zhao Y, Deverasetty S, Tebbe A, Schaab C, Lavery DJ, Howland D, Kwak S, Botas J, Aaronson JS, Rosinski J, Coppola G, Horvath S, Yang XW
Integrated genomics and proteomics define huntingtin CAG length-dependent networks in mice
Nat Neurosci
April 1, 2016
19 (4) :623-33
PMID: 26900923
Baake V, Hart EP, Bos R, Roos RA
Participants at the Leiden site of the REGISTRY Study: a demographic approach
J Huntingtons Dis
March 15, 2016
5 (1) :83-90
PMID: 27003663
Munoz-Sanjuan I
Support communities involved in disease studies
Nature
March 10, 2016
531 (7593) :141
PMID: 26961621
Fisher SP, Schwartz MD, Wurts-Black S, Thomas AM, Chen TM, Miller MA, Palmerston JB, Kilduff TS, Morairty SR
Quantitative electroencephalographic analysis provides an early-stage indicator of disease onset and progression in the zQ175 knock-in mouse model of Huntington's disease
Sleep
February 16, 2016
39 (2) :379-91
PMID: 26446107
PMCID: PMC4712407
Wiecki TV, Antoniades CA, Stevenson A, Kennard C, Borowsky B, Owen G, Leavitt B, Roos R, Durr A, Tabrizi SJ, Frank MJ
A computational cognitive biomarker for early-stage Huntington's disease
PLoS One
February 12, 2016
11 (2) :e0148409
PMID: 26872129
PMCID: PMC4752511
Keum JW, Shin A, Gillis T, Mysore JS, Abu Elneel K, Lucente D, Hadzi T, Holmans P, Jones L, Orth M, Kwak S, MacDonald ME, Gusella JF, Lee JM
The Htt CAG-expansion mutation determines age at death but not disease duration in Huntington disease
Am J Hum Genet
February 4, 2016
98 (2) :287-98
PMID: 26849111
PMCID: PMC4746370
Nambron R, Silajdžić E, Kalliolia E, Ottolenghi C, Hindmarsh P, Hill NR, Costelloe SJ, Martin NG, Positano V, Watt HC, Frost C, Björkqvist M, Warner TT
A metabolic study of Huntington's disease
PLoS One
January 8, 2016
11 (1) :e0146480
PMID: 26744893
PMCID: PMC4706313
Benraiss A, Wang S, Herrlinger S, Li X, Chandler-Militello D, Mauceri J, Burm HB, Toner M, Osipovitch M, Jim Xu Q, Ding F, Wang F, Kang N, Kang J, Curtin PC, Brunner D, Windrem MS, Munoz-Sanjuan I, Nedergaard M, Goldman SA
Human glia can both induce and rescue aspects of disease phenotype in Huntington disease
Nat Commun
January 1, 2016
7 :43843
PMID: 27273432
PMCID: PMC4899632
Culver BP, DeClercq J, Dolgalev I, Yu MS, Ma B, Heguy A, Tanese N
Huntington`s Disease protein Huntingtin associates with its own mRNA
J Huntingtons Dis
January 1, 2016
5 (1) :39-51
PMID: 26891106
PMCID: PMC4927879
Keogh R, Frost C, Owen G, Daniel RM, Langbehn DR, Leavitt B, Durr A, Roos RA, Landwehrmeyer GB, Reilmann R, Borowsky B, Stout J, Craufurd D, Tabrizi SJ
Medication use in early-HD participants in Track-HD: an investigation of its effects on clinical performance
PLoS Curr
January 1, 2016
8
PMID: 26819833
PMCID: PMC4718719
Carvalho JO, Long JD, Westervelt HJ, Smith MM, Bruce JM, Kim JI, Mills JA, Paulsen JS, PREDICT-HD Investigators and Coordinators of The Huntington Study Group
The impact of oculomotor functioning on neuropsychological performance in Huntington disease
J Clin Exp Neuropsychol
January 1, 2016
38 (2) :217-26
PMID: 26745770
Gregory S, Cole JH, Farmer RE, Rees EM, Roos RA, Sprengelmeyer R, Durr A, Landwehrmeyer B, Zhang H, Scahill RI, Tabrizi SJ, Frost C, Hobbs NZ
Longitudinal diffusion tensor imaging shows progressive changes in white matter in Huntington's disease
J Huntingtons Dis
December 27, 2015
4 (4) :333-46
PMID: 26756590
Puigdellivol M, Cherubini M, Brito V, Giralt A, Suelves N, Ballesteros J, Zamora-Moratalla A, Martin ED, Eipper BA, Alberch J, Gines S
A role for Kalirin-7 in corticostriatal synaptic dysfunction in Huntington`s disease
Hum Mol Genet
December 20, 2015
24 (25) :7265-85
PMID: 26464483
PMCID: PMC4664166
Dominguez DJF, Stout JC, Poudel G, Churchyard A, Chua P, Egan GF, Georgiou-Karistianis N
Multimodal imaging biomarkers in premanifest and early Huntington`s disease: 30-month IMAGE-HD data
Br J Psychiatry
December 17, 2015
208 (6) :571-8
PMID: 26678864
Luckhurst CA, Breccia P, Stott AJ, Aziz O, Birch HL, Bürli RW, Hughes SJ, Jarvis RE, Lamers M, Leonard PM, Matthews KL, McAllister G, Pollack S, Saville-Stones E, Wishart G, Yates D, Dominguez C
Potent, selective, and CNS-penetrant tetrasubstituted cyclopropane class IIa Histone Deacetylase (HDAC) Inhibitors
ACS Med Chem Lett
December 10, 2015
7 (1) :34-9
PMID: 26819662
PMCID: PMC4716601
Ring KL, An MC, Zhang N, O’Brien RN, Ramos EM, Gao F, Atwood R, Bailus BJ, Melov S, Mooney SD, Coppola G, Ellerby LM
Genomic analysis reveals disruption of striatal neuronal development and therapeutic targets in human Huntington's disease neural stem cells
Stem Cell Reports
December 8, 2015
5 (6) :1023-1038
PMID: 26651603
PMCID: PMC4682390
Dickey AS, Pineda VV, Tsunemi T, Liu PP, Miranda HC, Gilmore-Hall SK, Lomas N, Sampat KR, Buttgereit A, Torres MM, Flores AL, Arreola M, Arbez N, Akimov SS, Gaasterland T, Lazarowski ER, Ross CA, Yeo GW, Sopher BL, Magnuson GK, Pinkerton AB, Masliah E, La Spada AR
PPAR-delta is repressed in Huntington`s disease, is required for normal neuronal function and can be targeted therapeutically
Nat Med
December 7, 2015
22 (1) :37-45
PMID: 26642438
Banez-Coronel M, Ayhan F, Tarabochia AD, Zu T, Perez BA, Tusi SK, Pletnikova O, Borchelt DR, Ross CA, Margolis RL, Yachnis AT, Troncoso JC, Ranum LP
RAN translation in Huntington disease
Neuron
November 18, 2015
88 (4) :667-77
PMID: 26590344
PMCID: PMC4684947
Liu WC, Kohn J, Szwed SK, Pariser E, Sepe S, Haripal B, Oshimori N, Marsala M, Miyanohara A, Lee R
Human mutant huntingtin disrupts vocal learning in transgenic songbirds
Nat Neurosci
November 1, 2015
18 (11) :1617-22
PMID: 26436900
McColgan P, Seunarine KK, Razi A, Cole JH, Gregory S, Durr A, Roos RA, Stout JC, Landwehrmeyer B, Scahill RI, Clark CA, Rees G, Tabrizi SJ, Track-HD Investigators
Selective vulnerability of Rich Club brain regions is an organizational principle of structural connectivity loss in Huntington`s disease
Brain
November 1, 2015
138 (Pt 11) :3327-44
PMID: 26384928
Politis M, Lahiri N, Niccolini F, Su P, Wu K, Giannetti P, Scahill RI, Turkheimer FE, Tabrizi SJ, Piccini P
Increased central microglial activation associated with peripheral cytokine levels in premanifest Huntington`s disease gene carriers
Neurobiol Dis
November 1, 2015
83 :115-21
PMID: 26297319
Epping EA, Kim JI, Craufurd D, Brashers-Krug TM, Anderson KE, McCusker E, Luther J, Long JD, Paulsen JS, Predict-Hd Investigators, Coordinators of the Huntington Study Group
Longitudinal psychiatric symptoms in prodromal Huntington`s disease: a decade of data
Am J Psychiatry
October 16, 2015
173 (2) :184-92
PMID: 26472629
Minkova L, Eickhoff SB, Abdulkadir A, Kaller CP, Peter J, Scheller E, Lahr J, Roos RA, Durr A, Leavitt BR, Tabrizi SJ, Kloppel S, Track-HD Investigators
Large-scale brain network abnormalities in Huntington`s disease revealed by structural covariance
Hum Brain Mapp
October 10, 2015
37 (1) :67-80
PMID: 26453902
Long JD, Paulsen JS, Predict-HD Investigators, Coordinators of the Huntington Study Group
Multivariate prediction of motor diagnosis in Huntington`s disease: 12 years of PREDICT-HD
Mov Disord
October 1, 2015
30 (12) :1664-72
PMID: 26340420
Lazar AS, Panin F, Goodman AO, Lazic SE, Lazar ZI, Mason SL, Rogers L, Murgatroyd PR, Watson LP, Singh P, Borowsky B, Shneerson JM, Barker RA
Sleep deficits but no metabolic deficits in premanifest Huntington`s disease
Ann Neurol
October 1, 2015
78 (4) :630-48
PMID: 26224419
Matsui JT, Vaidya JG, Wassermann D, Kim RE, Magnotta VA, Johnson HJ, Paulsen JS, Predict-HD Investigators, Coordinators of the Huntington Study Group
Prefrontal cortex white matter tracts in prodromal Huntington disease
Hum Brain Mapp
October 1, 2015
36 (10) :3717-32
PMID: 26179962
PMCID: PMC4583330
Kim JI, Long JD, Mills JA, Downing N, Williams JK, Paulsen JS, Predict-HD Investigators, Coordinators of the Huntington Study Group
Performance of the 12-item WHODAS 2.0 in prodromal Huntington disease
Eur J Hum Genet
October 1, 2015
23 (11) :1584-7
PMID: 25735480
Correia K, Harold D, Kim KH, Holmans P, Jones L, Orth M, Myers RH, Kwak S, Wheeler VC, MacDonald ME, Gusella JF, Lee JM
The Genetic Modifiers of Motor OnsetAge (GeM MOA) website: Genome-wide association analysis for genetic modifiers of Huntington`s disease
J Huntingtons Dis
September 29, 2015
4 (3) :279-84
PMID: 26444025
Beglinger LJ, Adams WH, Fiedorowicz JG, Duff K, Langbehn D, Biglan K, Caviness J, Olson B, Paulsen JS
Practice effects and stability of neuropsychological and UHDRS tests over short retest intervals in Huntington disease
J Huntingtons Dis
September 29, 2015
4 (3) :251-60
PMID: 26444022
Johnson E, Chase K, McGowan S, Mondo E, Pfister E, Mick E, Friedline RH, Kim JK, Sapp E, DiFiglia M, Aronin N
Safety of striatal infusion of siRNA in a transgenic Huntington`s disease mouse model
J Huntingtons Dis
September 29, 2015
4 (3) :219-29
PMID: 26444021
Gregory S, Scahill RI, Seunarine KK, Stopford C, Zhang H, Zhang J, Orth M, Durr A, Roos RA, Langbehn DR, Long JD, Johnson H, Rees G, Tabrizi SJ, Craufurd D
Neuropsychiatry and white matter microstructure in Huntington`s disease
J Huntingtons Dis
September 29, 2015
4 (3) :239-49
PMID: 26443926
PMCID: PMC4684097
Liu D, Long JD, Zhang Y, Raymond LA, Marder K, Rosser A, McCusker EA, Mills JA, Paulsen JS, Predict-HD Investigators, Coordinators of the Huntington Study Group
Motor onset and diagnosis in Huntington disease using the diagnostic confidence level
J Neurol
September 26, 2015
262 (12) :2691-8
PMID: 26410751
Straccia M, Garcia-Diaz Barriga G, Sanders P, Bombau G, Carrere J, Mairal PB, Vinh NN, Yung S, Kelly CM, Svendsen CN, Kemp PJ, Arjomand J, Schoenfeld RC, Alberch J, Allen ND, Rosser AE, Canals JM
Quantitative high-throughput gene expression profiling of human striatal development to screen stem cell-derived medium spiny neurons
Mol Ther Methods Clin Dev
September 16, 2015
2 :15030
PMID: 26417608
PMCID: PMC4571731
Gatto RG, Chu Y, Ye AQ, Price SD, Tavassoli E, Buenaventura A, Brady ST, Magin RL, Kordower JH, Morfini GA
Analysis of YFP(J16)-R6/2 reporter mice and postmortem brains reveals early pathology and increased vulnerability of callosal axons in Huntington`s disease
Hum Mol Genet
September 15, 2015
24 (18) :5285-98
PMID: 26123489
PMCID: PMC4550824
Ciamei A, Detloff PJ, Morton AJ
Progression of behavioural despair in R6/2 and Hdh knock-in mouse models recapitulates depression in Huntington`s disease
Behav Brain Res
September 15, 2015
291 :140-6
PMID: 25986402
Bustamante MB, Ansaloni A, Pedersen JF, Azzollini L, Cariulo C, Wang ZM, Petricca L, Verani M, Puglisi F, Park H, Lashuel H, Caricasole A
Detection of huntingtin exon 1 phosphorylation by Phos-Tag SDS-PAGE: Predominant phosphorylation on threonine 3 and regulation by IKKbeta
Biochem Biophys Res Commun
August 7, 2015
463 (4) :1317-22
PMID: 26106822
Kloppel S, Gregory S, Scheller E, Minkova L, Razi A, Durr A, Roos RAC, Leavitt BR, Papoutsi M, Landwehrmeyer GB, Reilmann R, Borowsky B, Johnson H, Mills JA, Owen G, Stout J, Scahill RI, Long JD, Rees G, Tabrizi SJ
Compensation in preclinical Huntington`s disease: evidence from the Track-On HD study
E Bio Medicine
August 4, 2015
2 (10) :1420-9
PMID: 26629536
PMCID: 4634199