CHDI
Listed here are over 1000 publications that describe some of the research funded (in whole or in part) by CHDI Foundation. You can also view just the subset of publications that have CHDI staff as authors.
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Title
Journal
Lazar AS, Panin F, Goodman AO, Lazic SE, Lazar ZI, Mason SL, Rogers L, Murgatroyd PR, Watson LP, Singh P, Borowsky B, Shneerson JM, Barker RA
Sleep deficits but no metabolic deficits in premanifest Huntington`s disease
Matsui JT, Vaidya JG, Wassermann D, Kim RE, Magnotta VA, Johnson HJ, Paulsen JS, Predict-HD Investigators, Coordinators of the Huntington Study Group
Prefrontal cortex white matter tracts in prodromal Huntington disease
Hum Brain Mapp
October 1, 2015
36 (10) :3717-32
36 (10) :3717-32
PMID: 26179962
PMCID: PMC4583330
DOI: 10.1002/hbm.22835
Kim JI, Long JD, Mills JA, Downing N, Williams JK, Paulsen JS, Predict-HD Investigators, Coordinators of the Huntington Study Group
Performance of the 12-item WHODAS 2.0 in prodromal Huntington disease
Correia K, Harold D, Kim KH, Holmans P, Jones L, Orth M, Myers RH, Kwak S, Wheeler VC, MacDonald ME, Gusella JF, Lee JM
The Genetic Modifiers of Motor OnsetAge (GeM MOA) website: Genome-wide association analysis for genetic modifiers of Huntington`s disease
Beglinger LJ, Adams WH, Fiedorowicz JG, Duff K, Langbehn D, Biglan K, Caviness J, Olson B, Paulsen JS
Practice effects and stability of neuropsychological and UHDRS tests over short retest intervals in Huntington disease
Johnson E, Chase K, McGowan S, Mondo E, Pfister E, Mick E, Friedline RH, Kim JK, Sapp E, DiFiglia M, Aronin N
Safety of striatal infusion of siRNA in a transgenic Huntington`s disease mouse model
Gregory S, Scahill RI, Seunarine KK, Stopford C, Zhang H, Zhang J, Orth M, Durr A, Roos RA, Langbehn DR, Long JD, Johnson H, Rees G, Tabrizi SJ, Craufurd D
Neuropsychiatry and white matter microstructure in Huntington`s disease
J Huntingtons Dis
September 29, 2015
4 (3) :239-49
4 (3) :239-49
PMID: 26443926
PMCID: PMC4684097
DOI: 10.3233/JHD-150160
Liu D, Long JD, Zhang Y, Raymond LA, Marder K, Rosser A, McCusker EA, Mills JA, Paulsen JS, Predict-HD Investigators, Coordinators of the Huntington Study Group
Motor onset and diagnosis in Huntington disease using the diagnostic confidence level
Straccia M, Garcia-Diaz Barriga G, Sanders P, Bombau G, Carrere J, Mairal PB, Vinh NN, Yung S, Kelly CM, Svendsen CN, Kemp PJ, Arjomand J, Schoenfeld RC, Alberch J, Allen ND, Rosser AE, Canals JM
Quantitative high-throughput gene expression profiling of human striatal development to screen stem cell-derived medium spiny neurons
Mol Ther Methods Clin Dev
September 16, 2015
2 :15030
2 :15030
PMID: 26417608
PMCID: PMC4571731
DOI: 10.1038/mtm.2015.30
Gatto RG, Chu Y, Ye AQ, Price SD, Tavassoli E, Buenaventura A, Brady ST, Magin RL, Kordower JH, Morfini GA
Analysis of YFP(J16)-R6/2 reporter mice and postmortem brains reveals early pathology and increased vulnerability of callosal axons in Huntington`s disease
Hum Mol Genet
September 15, 2015
24 (18) :5285-98
24 (18) :5285-98
PMID: 26123489
PMCID: PMC4550824
DOI: 10.1093/hmg/ddv248
Ciamei A, Detloff PJ, Morton AJ
Progression of behavioural despair in R6/2 and Hdh knock-in mouse models recapitulates depression in Huntington`s disease
Bustamante MB, Ansaloni A, Pedersen JF, Azzollini L, Cariulo C, Wang ZM, Petricca L, Verani M, Puglisi F, Park H, Lashuel H, Caricasole A
Detection of huntingtin exon 1 phosphorylation by Phos-Tag SDS-PAGE: Predominant phosphorylation on threonine 3 and regulation by IKKbeta
Biochem Biophys Res Commun
August 7, 2015
463 (4) :1317-22
463 (4) :1317-22
PMID: 26106822
Kloppel S, Gregory S, Scheller E, Minkova L, Razi A, Durr A, Roos RAC, Leavitt BR, Papoutsi M, Landwehrmeyer GB, Reilmann R, Borowsky B, Johnson H, Mills JA, Owen G, Stout J, Scahill RI, Long JD, Rees G, Tabrizi SJ
Compensation in preclinical Huntington`s disease: evidence from the Track-On HD study
Arrowsmith CH, Audia JE, Austin C, Baell J, Bennett J, Blagg J, Bountra C, Brennan PE, Brown PJ, Bunnage ME, Buser-Doepner C, Campbell RM, Carter AJ, Cohen P, Copeland RA, Cravatt B, Dahlin JL, Dhanak D, Edwards AM, Frye SV, Gray N, Grimshaw CE, Hepworth D, Howe T, Huber KV, Jin J, Knapp S, Kotz JD, Kruger RG, Lowe D, Mader MM, Marsden B, Mueller-Fahrnow A, Muller S, O`Hagan RC, Overington JP, Owen DR,…Zuercher WJ
The promise and peril of chemical probes
Harrington DL, Rubinov M, Durgerian S, Mourany L, Reece C, Koenig K, Bullmore E, Long JD, Paulsen JS, Predict-Hd investigators of the Huntington Study Group, Rao SM
Network topology and functional connectivity disturbances precede the onset of Huntington`s disease
Plotkin JL, Surmeier DJ
Corticostriatal synaptic adaptations in Huntington`s disease
O`Brien R, DeGiacomo F, Holcomb J, Bonner A, Ring KL, Zhang N, Zafar K, Weiss A, Lager B, Schilling B, Gibson BW, Chen S, Kwak S, Ellerby LM
Integration-independent transgenic Huntington disease fragment mouse models reveal distinct phenotypes and life span in vivo
GeM-HD Consortium
Identification of genetic factors that modify clinical onset of Huntington`s disease
Sun X, Li PP, Zhu S, Cohen R, Marque LO, Ross CA, Pulst SM, Chan HY, Margolis RL, Rudnicki DD
Nuclear retention of full-length HTT RNA is mediated by splicing factors MBNL1 and U2AF65
Khakh BS, Sofroniew MV
Diversity of astrocyte functions and phenotypes in neural circuits
Achour M, Le Gras S, Keime C, Parmentier F, Lejeune FX, Boutillier AL, Néri C, Davidson I, Merienne K
Neuronal identity genes regulated by super-enhancers are preferentially down-regulated in the striatum of Huntington's disease mice
Friedman A, Homma D, Gibb LG, Amemori K, Rubin SJ, Hood AS, Riad MH, Graybiel AM
A corticostriatal path targeting striosomes controls decision-making under conflict
Becanovic K, Norremolle A, Neal SJ, Kay C, Collins JA, Arenillas D, Lilja T, Gaudenzi G, Manoharan S, Doty CN, Beck J, Lahiri N, Portales-Casamar E, Warby SC, Connolly C, De Souza RA, Registry Investigators of the European Huntington`s Disease Network, Tabrizi SJ, Hermanson O, Langbehn DR, Hayden MR, Wasserman WW, Leavitt BR
A SNP in the HTT promoter alters NF-kappaB binding and is a bidirectional genetic modifier of Huntington disease
Odish OF, Leemans A, Reijntjes RH, van den Bogaard SJ, Dumas EM, Wolterbeek R, Tax CM, Kuijf HJ, Vincken KL, van der Grond J, Roos RA
Microstructural brain abnormalities in Huntington`s disease: A two-year follow-up
Dominguez JF, Ng AC, Poudel G, Stout JC, Churchyard A, Chua P, Egan GF, Georgiou-Karistianis N
Iron accumulation in the basal ganglia in Huntington`s disease: cross-sectional data from the IMAGE-HD study
J Neurol Neurosurg Psychiatry
May 7, 2015
87 (5) :545-9
87 (5) :545-9
PMID: 25952334
Wild EJ, Boggio R, Langbehn D, Robertson N, Haider S, Miller JR, Zetterberg H, Leavitt BR, Kuhn R, Tabrizi SJ, Macdonald D, Weiss A
Quantification of mutant huntingtin protein in cerebrospinal fluid from Huntington`s disease patients
Novak MJ, Seunarine KK, Gibbard CR, McColgan P, Draganski B, Friston K, Clark CA, Tabrizi SJ
Basal ganglia-cortical structural connectivity in Huntington`s disease
Jin J, Peng Q, Hou Z, Jiang M, Wang X, Langseth AJ, Tao M, Barker PB, Mori S, Bergles DE, Ross CA, Detloff PJ, Zhang J, Duan W
Early white matter abnormalities, progressive brain pathology and motor deficits in a novel knock-in mouse model of Huntington`s disease
Biagioli M, Ferrari F, Mendenhall EM, Zhang Y, Erdin S, Vijayvargia R, Vallabh SM, Solomos N, Manavalan P, Ragavendran A, Ozsolak F, Lee JM, Talkowski ME, Gusella JF, Macdonald ME, Park PJ, Seong IS
Htt CAG repeat expansion confers pleiotropic gains of mutant huntingtin function in chromatin regulation
Wityak J, McGee KF, Conlon MP, Song RH, Duffy BC, Clayton B, Lynch M, Wang G, Freeman E, Haber J, Kitchen DB, Manning DD, Ismail J, Khmelnitsky Y, Michels P, Webster J, Irigoyen M, Luche M, Hultman M, Bai M, Kuok ID, Newell R, Lamers M, Leonard P, Yates D, Matthews K, Ongeri L, Clifton S, Mead T, Deupree S, Wheelan P, Lyons K, Wilson C, Kiselyov A, Toledo-Sherman L, Beconi M, Muñoz-Sanjuan I, Bard J, Dominguez C
Lead optimization toward proof-of-concept tools for Huntington's disease within a 4-(1H-pyrazol-4-yl) pyrimidine class of pan-JNK inhibitors
Larson E, Fyfe I, Morton AJ, Monckton DG
Age-, tissue- and length-dependent bidirectional somatic CAG•CTG repeat instability in an allelic series of R6/2 Huntington disease mice
Sanders SS, Hayden MR
Aberrant palmitoylation in Huntington disease
Hering T, Birth N, Taanman JW, Orth M
Selective striatal mtDNA depletion in end-stage Huntington`s disease R6/2 mice
Khakh BS, McCarthy KD
Astrocyte calcium signaling: from observations to functions and the challenges therein
Cold Spring Harb Perspect Biol
April 1, 2015
7 (4) :a020404
7 (4) :a020404
PMID: 25605709
Valenza M, Marullo M, Di Paolo E, Cesana E, Zuccato C, Biella G, Cattaneo E
Disruption of astrocyte-neuron cholesterol cross talk affects neuronal function in Huntington`s disease
Cell Death Differ
April 1, 2015
22 (4) :690-702
22 (4) :690-702
PMID: 25301063
PMCID: 4356339
DOI: 10.1038/cdd.2014.162
Wassef SN, Wemmie J, Johnson CP, Johnson H, Paulsen JS, Long JD, Magnotta VA
T1rho imaging in premanifest Huntington disease reveals changes associated with disease progression
Orsatti L, Speziale R, Orsale MV, Caretti F, Veneziano M, Zini M, Monteagudo E, Lyons K, Beconi M, Chan K, Herbst T, Toledo-Sherman L, Munoz-Sanjuan I, Bonelli F, Dominguez C
A single-run liquid chromatography mass spectrometry method to quantify neuroactive kynurenine pathway metabolites in rat plasma
Huang B, Lucas T, Kueppers C, Dong X, Krause M, Bepperling A, Buchner J, Voshol H, Weiss A, Gerrits B, Kochanek S
Scalable production in human cells and biochemical characterization of full-length normal and mutant huntingtin
Penrose SD, Stott AJ, Breccia P, Haughan AF, Burli RW, Jarvis RE, Dominguez C
Inter- and intramolecular annulation strategies to a cyclopentanone building block containing an all-carbon quaternary stereogenic center
Cheng HM, Chern Y, Chen IH, Liu CR, Li SH, Chun SJ, Rigo F, Bennett CF, Deng N, Feng Y, Lin CS, Yan YT, Cohen SN, Cheng TH
Effects on murine behavior and lifespan of selectively decreasing expression of mutant huntingtin allele by supt4h knockdown