Scientific Publications

Listed here are over 900 publications that describe some of the research funded (in whole or in part) by CHDI Foundation. You can also view just the subset of publications that have CHDI staff as authors.

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Goold R, Hamilton J, Menneteau T, Flower M, Bunting EL, Aldous SG, Porro A, Vicente JR, Allen ND, Wilkinson H, Bates GP, Sartori AA, Thalassinos K, Balmus G, Tabrizi SJ
FAN1 controls mismatch repair complex assembly via MLH1 retention to stabilize CAG repeat expansion in Huntington's disease
Cell Rep
August 31, 2021
36 (9) :109649
PMID: 34469738
Liu L, Johnson PD, Prime ME, Khetarpal V, Lee MR, Brown CJ, Chen X, Clark-Frew D, Coe S, Conlon M, Davis R, Ensor S, Esposito S, Moren AF, Gai X, Green S, Greenaway C, Haber J, Halldin C, Hayes S, Herbst T, Herrmann F, Heßmann M, Hsai MM, Kotey A, Mangette JE, Mills MR, Monteagudo E, Nag S, Nibbio M, Orsatti L, Schaertl S, …Dominguez C
[11C]CHDI-626, a PET tracer candidate for imaging mutant huntingtin aggregates with reduced binding to AD pathological proteins
J Med Chem
August 26, 2021
64 (16) :12003-12021
PMID: 34351166
Lunven M, Hamet Bagnou J, Youssov K, Gabadinho A, Fliss R, Montillot J, Audureau E, Bapst B, Morgado G, Reilmann R, Schubert R, Busse M, Craufurd D, Massart R, Rosser A, Bachoud-Lévi AC
Cognitive decline in Huntington's disease in the Digitalized Arithmetic Task (DAT)
PLoS One
August 23, 2021
16 (8) :e0253064
PMID: 34424902
PMCID: 8382187
Sathe S, Ware J, Levey J, Neacy E, Blumenstein R, Noble S, Mühlbäck A, Rosser A, Landwehrmeyer GB, Sampaio C
Enroll-HD: An integrated clinical research platform and worldwide observational study for Huntington's disease
Front Neurol
August 18, 2021
12 :667420
PMID: 34484094
PMCID: 8416308
Schulze-Krebs A, Canneva F, Stemick J, Plank AC, Harrer J, Bates GP, Aeschlimann D, Steffan JS, von Hörsten S
Transglutaminase 6 is colocalized and interacts with mutant huntingtin in Huntington disease rodent animal models
Int J Mol S
August 18, 2021
22 (16) :8914
PMID: 34445621
PMCID: 8396294
Wijeratne PA, Johnson EB, Gregory S, Georgiou-Karistianis N, Paulsen JS, Scahill RI, Tabrizi SJ, Alexander DC
A multi-study model-based evaluation of the sequence of imaging and clinical biomarker changes in Huntington's disease
Front Big Data
August 5, 2021
4 :662200
PMID: 34423286
PMCID: 8374237
Wang Y, Guo X, Ye K, Orth M, Gu Z
Accelerated expansion of pathogenic mitochondrial DNA heteroplasmies in Huntington's disease
Proc Natl Acad Sci USA
July 27, 2021
118 (30) :e2014610118
PMID: 34301881
Raj A, Powell F
Network model of pathology spread recapitulates neurodegeneration and selective vulnerability in Huntington's disease
Neuroimage
July 15, 2021
235 :118008
PMID: 33789134
Abreu D, Ware J, Georgiou-Karistianis N, Leavitt BR, Fitzer-Attas CJ, Lobo R, Fernandes AR, Handley O, Anderson KE, Stout JC, Sampaio C
Utility of Huntington's disease assessments by disease stage: Floor/ceiling effects
Front Neurol
July 15, 2021
12 :595679
PMID: 34335433
PMCID: 8320772
Mario Isas J, Pandey NK, Xu H, Teranishi K, Okada AK, Fultz EK, Rawat A, Applebaum A, Meier F, Chen J, Langen R, Siemer AB
Huntingtin fibrils with different toxicity, structure, and seeding potential can be interconverted
Nat Commun
July 13, 2021
12 (1) :4272
PMID: 34257293
PMCID: 8277859
Zhang Y, Zhou J, Gehl CR, Long JD, Johnson H, Magnotta VA, Sewell D, Shannon K, Paulsen JS
Mild cognitive impairment as an early landmark in Huntington's disease
Front Neurol
July 7, 2021
12 :678652
PMID: 34305789
PMCID: 8292715
Kolla R, Gopinath P, Ricci J, Reif A, Rostami I, Lashuel HA
A new chemoenzymatic semisynthetic approach provides insight into the role of phosphorylation beyond exon1 of huntingtin and reveals n-terminal fragment length-dependent distinct mechanisms of aggregation
J Am Chem Soc
July 7, 2021
143 (26) :9798-9812
PMID: 34161085
Benraiss A, Mariani JN, Osipovitch M, Cornwell A, Windrem MS, Villanueva CB, Chandler-Militello D, Goldman SA
Cell-intrinsic glial pathology is conserved across human and murine models of Huntington's disease
Cell Rep
July 6, 2021
36 (1) :109308
PMID: 34233199
Rodrigues FB, Byrne LM, Lowe AJ, Tortelli R, Heins M, Flik G, Johnson EB, De Vita E, Scahill RI, Giorgini F, Wild EJ
Kynurenine pathway metabolites in cerebrospinal fluid and blood as potential biomarkers in Huntington's disease
J Neurochem
July 1, 2021
158 (2) :539-553
PMID: 33797782
PMCID: 8375100
Malaiya S, Cortes-Gutierrez M, Herb BR, Coffey SR, Legg SRW, Cantle JP, Colantuoni C, Carroll JB, Ament SA
Single-nucleus RNA-seq reveals dysregulation of striatal cell identity due to Huntington's disease mutations
J Neurosci
June 23, 2021
41 (25) :5534-5552
PMID: 34011527
Schindler F, Praedel N, Neuendorf N, Kunz S, Schnoegl S, Mason MA, Taxy BA, Bates GP, Khoshnan A, Priller J, Grimm J, Maier M, Boeddrich A, Wanker EE
Small, seeding-competent huntingtin fibrils are prominent aggregate species in brains of zQ175 Huntington's disease knock-in mice
Front Neurosci
June 22, 2021
15 :682172
PMID: 34239412
PMCID: 8257939
Seeley C, Kegel-Gleason KB
Taming the Huntington's disease proteome: What have we learned?
J Huntingtons Dis
June 9, 2021
10 (2) :239-257
PMID: 33998547
PMCID: 8293646
Rivetti di Val Cervo P, Besusso D, Conforti P, Cattaneo E
hiPSCs for predictive modelling of neurodegenerative diseases: dreaming the possible
Nat Rev Neurol
June 1, 2021
17 (6) :381-392
PMID: 33658662
PMCID: 7928200
McAllister B, Gusella JF, Landwehrmeyer GB, Lee JM, MacDonald ME, Orth M, Rosser AE, Williams NM, Holmans P, Jones L, Massey TH, REGISTRY investigators of the European Huntington’s disease network
Timing and impact of psychiatric, cognitive, and motor abnormalities in Huntington disease
Neurology
May 11, 2021
96 (19) :e2395-e2406
PMID: 33766994
Bocchi VD, Conforti P, Vezzoli E, Besusso D, Cappadona C, Lischetti T, Galimberti M, Ranzani V, Bonnal RJP, De Simone M, Rossetti G, He X, Kamimoto K, Espuny-Camacho I, Faedo A, Gervasoni F, Vuono R, Morris SA, Chen J, Felsenfeld D, Pavesi G, Barker RA, Pagani M, Cattaneo E
The coding and long noncoding single-cell atlas of the developing human fetal striatum
Science
May 7, 2021
372 (6542) :eabf5759
PMID: 33958447
Deng Y, Wang H, Joni M, Sekhri R, Reiner A
Progression of basal ganglia pathology in heterozygous Q175 knock-in Huntington's disease mice
J Comp Neurol
May 1, 2021
529 (7) :1327-1371
PMID: 32869871
PMCID: 8049038
Gomez-Paredes C, Mason MA, Taxy BA, Papadopoulou AS, Paganetti P, Bates GP
The heat shock response, determined by QuantiGene multiplex, is impaired in HD mouse models and not caused by HSF1 reduction
Sci Rep
April 27, 2021
11 (1) :9117
PMID: 33907289
Jung R, Lee Y, Barker D, Correia K, Shin B, Loupe J, Collins RL, Lucente D, Ruliera J, Gillis T, Mysore JS, Rodan L, Picker J, Lee JM, Howland D, Lee R, Kwak S, MacDonald ME, Gusella JF, Seong IS
Mutations causing Lopes-Maciel-Rodan syndrome are huntingtin hypomorphs
Hum Mol Genet
April 26, 2021
30 (3-4) :135-148
PMID: 33432339
Van de Poël A, Toledo-Sherman L, Breccia P, Cachope R, Bate JR, Angulo-Herrera I, Wishart G, Matthews KL, Martin SL, Peacock M, Barnard A, Cox HC, Jones G, McAllister G, Vater H, Esmieu W, Clissold C, Lamers M, Leonard P, Jarvis RE, Blackaby W, Eznarriaga M, Lazari O, Yates D, Rose M, Jang SW, Muñoz-Sanjuan I, Dominguez C
Structure-based exploration of selectivity for ATM inhibitors in Huntington's disease
J Med Chem
April 22, 2021
64 (8) :5018-5036
PMID: 33783225
Onur TS, Laitman A, Zhao H, Keyho R, Kim H, Wang J, Mair M, Wang H, Li L, Perez A, de Haro M, Wan YW, Allen G, Lu B, Al-Ramahi I, Liu Z, Botas J
Downregulation of glial genes involved in synaptic function mitigates Huntington's disease pathogenesis
Elife
April 19, 2021
10 :e64564
PMID: 33871358
Zhou Y, Peskett TR, Landles C, Warner JB, Sathasivam K, Smith EJ, Chen S, Wetzel R, Lashuel HA, Bates GP, Saibil HR
Correlative light and electron microscopy suggests that mutant huntingtin dysregulates the endolysosomal pathway in presymptomatic Huntington's disease
Acta Neuropathol Commun
April 14, 2021
9 (1) :70
PMID: 33853668
Johnson EB, Ziegler G, Penny W, Rees G, Tabrizi SJ, Scahill RI, Gregory S
Dynamics of cortical degeneration over a decade in Huntington's disease
Biol Psychiatry
April 13, 2021
89 (8) :807-816
PMID: 33500176
PMCID: 7986936
Vas S, Nicol AU, Kalmar L, Miles J, Morton AJ
Abnormal patterns of sleep and EEG power distribution during non-rapid eye movement sleep in the sheep model of Huntington's disease
Neurobiol Dis
April 10, 2021
155 :105367
PMID: 33848636
Vallès A, Evers MM, Stam A, Sogorb-Gonzalez M, Brouwers C, Vendrell-Tornero C, Acar-Broekmans S, Paerels L, Klima J, Bohuslavova B, Pintauro R, Fodale V, Bresciani A, Liscak R, Urgosik D, Starek Z, Crha M, Blits B, Petry H, Ellederova Z, Motlik J, van Deventer S, Konstantinova P
Widespread and sustained target engagement in Huntington's disease minipigs upon intrastriatal microRNA-based gene therapy
Sci Transl Med
April 7, 2021
13 (588) :eabb8920
PMID: 33827977
Bertoglio D, Verhaeghe J, Miranda A, Wyffels L, Stroobants S, Dominguez C, Munoz-Sanjuan I, Skinbjerg M, Liu L, Staelens S
Kinetic modelling and test-retest reproducibility for the dopamine D1R radioligand [11C]SCH23390 in healthy and diseased mice
Mol Imaging Biol
April 2, 2021
23 (2) :208-219
PMID: 33179158
PMCID: 7910372
Iuliano M, Seeley C, Sapp E, Jones EL, Martin C, Li X, DiFiglia M, Kegel-Gleason KB
Disposition of proteins and lipids in synaptic membrane compartments is altered in Q175/Q7 Huntington's disease mouse striatum
Front Synaptic Neurosci
March 18, 2021
13 :618391
PMID: 33815086
PMCID: 8013775
Khaled HG, Feng H, Hu X, Sun X, Zheng W, Li PP, Rudnicki DD, Ye W, Chen YC, Southall N, Marugan J, Ross CA, Ferrer M, Henderson MJ, Margolis RL
A high-throughput screening to identify small molecules that suppress huntingtin promoter activity or activate huntingtin-antisense promoter activity
Sci Rep
March 17, 2021
11 (1) :6157
PMID: 33731741
PMCID: 7969751
Stott AJ, Maillard MC, Beaumont V, Allcock D, Aziz O, Borchers AH, Blackaby W, Breccia P, Creighton-Gutteridge G, Haughan AF, Jarvis RE, Luckhurst CA, Matthews KL, McAllister G, Pollack S, Saville-Stones E, Van de Poël AJ, Vater HD, Vann J, Williams R, Yates D, Muñoz-Sanjuán I, Dominguez C
Evaluation of 5-(Trifluoromethyl)-1,2,4-oxadiazole-based class IIa HDAC inhibitors for Huntington's disease
ACS Med Chem Lett
March 11, 2021
12 (3) :380-388
PMID: 33738065
PMCID: 7957923
Johnson EB, Parker CS, Scahill RI, Gregory S, Papoutsi M, Zeun P, Osborne-Crowley K, Lowe J, Nair A, Estevez-Fraga C, Fayer K, Rees G, Zhang H, Tabrizi SJ, HD-YAS Investigators
Altered iron and myelin in premanifest Huntington's disease more than 20 years before clinical onset: Evidence from the cross-sectional HD Young Adult Study
EBioMedicine
March 8, 2021
65 :103266
PMID: 33706250
Eshraghi M, Karunadharma PP, Blin J, Shahani N, Ricci EP, Michel A, Urban NT, Galli N, Sharma M, Ramírez-Jarquín UN, Florescu K, Hernandez J, Subramaniam S
Mutant huntingtin stalls ribosomes and represses protein synthesis in a cellular model of Huntington disease
Nat Commun
March 5, 2021
12 (1) :1461
PMID: 33674575
Megret L, Gris B, Sasidharan Nair S, Cevost J, Wertz M, Aaronson J, Rosinski J, Vogt TF, Wilkinson H, Heiman M, Neri C
Shape deformation analysis reveals the temporal dynamics of cell-type-specific homeostatic and pathogenic responses to mutant huntingtin
Elife
February 23, 2021
10 :e64984
PMID: 33618800
PMCID: 7901871
Cachope R, Pereda AE
Regulatory roles of metabotropic glutamate receptors on synaptic communication mediated by gap junctions
Neuroscience
February 21, 2021
456 :85-94
PMID: 32619474
PMCID: 7805574
Vicente E, Ruiz de Sabando A, García F, Gastón I, Ardanaz E, Ramos-Arroyo MA
Validation of diagnostic codes and epidemiologic trends of Huntington disease: a population-based study in Navarre, Spain
Orphanet J Rare Dis
February 10, 2021
16 (1) :77
PMID: 33568143
PMCID: 7877055
Ou ZA, Byrne LM, Rodrigues FB, Tortelli R, Johnson EB, Foiani MS, Arridge M, De Vita E, Scahill RI, Heslegrave A, Zetterberg H, Wild EJ
Brain-derived neurotrophic factor in cerebrospinal fluid and plasma is not a biomarker for Huntington's disease
Sci Rep
February 10, 2021
11 (1) :3481
PMID: 33568689
Wheeler VC, Dion V
Modifiers of CAG/CTG repeat instability: Insights from mammalian models
J Huntingtons Dis
February 9, 2021
10 (1) :123-148
PMID: 33579861