CHDI
Listed here are over 1,075 publications that describe some of the research funded (in whole or in part) by CHDI Foundation. You can also view just the subset of publications that have CHDI staff as authors.
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Title
Journal
Wild EJ, Boggio R, Langbehn D, Robertson N, Haider S, Miller JR, Zetterberg H, Leavitt BR, Kuhn R, Tabrizi SJ, Macdonald D, Weiss A
Quantification of mutant huntingtin protein in cerebrospinal fluid from Huntington`s disease patients
Novak MJ, Seunarine KK, Gibbard CR, McColgan P, Draganski B, Friston K, Clark CA, Tabrizi SJ
Basal ganglia-cortical structural connectivity in Huntington`s disease
Jin J, Peng Q, Hou Z, Jiang M, Wang X, Langseth AJ, Tao M, Barker PB, Mori S, Bergles DE, Ross CA, Detloff PJ, Zhang J, Duan W
Early white matter abnormalities, progressive brain pathology and motor deficits in a novel knock-in mouse model of Huntington`s disease
Biagioli M, Ferrari F, Mendenhall EM, Zhang Y, Erdin S, Vijayvargia R, Vallabh SM, Solomos N, Manavalan P, Ragavendran A, Ozsolak F, Lee JM, Talkowski ME, Gusella JF, Macdonald ME, Park PJ, Seong IS
Htt CAG repeat expansion confers pleiotropic gains of mutant huntingtin function in chromatin regulation
Wityak J, McGee KF, Conlon MP, Song RH, Duffy BC, Clayton B, Lynch M, Wang G, Freeman E, Haber J, Kitchen DB, Manning DD, Ismail J, Khmelnitsky Y, Michels P, Webster J, Irigoyen M, Luche M, Hultman M, Bai M, Kuok ID, Newell R, Lamers M, Leonard P, Yates D, Matthews K, Ongeri L, Clifton S, Mead T, Deupree S, Wheelan P, Lyons K, Wilson C, Kiselyov A, Toledo-Sherman L, Beconi M, Muñoz-Sanjuan I, Bard J, Dominguez C
Lead optimization toward proof-of-concept tools for Huntington's disease within a 4-(1H-pyrazol-4-yl) pyrimidine class of pan-JNK inhibitors
Larson E, Fyfe I, Morton AJ, Monckton DG
Age-, tissue- and length-dependent bidirectional somatic CAG•CTG repeat instability in an allelic series of R6/2 Huntington disease mice
Sanders SS, Hayden MR
Aberrant palmitoylation in Huntington disease
Hering T, Birth N, Taanman JW, Orth M
Selective striatal mtDNA depletion in end-stage Huntington`s disease R6/2 mice
Khakh BS, McCarthy KD
Astrocyte calcium signaling: from observations to functions and the challenges therein
Cold Spring Harb Perspect Biol
April 1, 2015
7 (4) :a020404
7 (4) :a020404
PMID: 25605709
Valenza M, Marullo M, Di Paolo E, Cesana E, Zuccato C, Biella G, Cattaneo E
Disruption of astrocyte-neuron cholesterol cross talk affects neuronal function in Huntington`s disease
Cell Death Differ
April 1, 2015
22 (4) :690-702
22 (4) :690-702
PMID: 25301063
PMCID: 4356339
DOI: 10.1038/cdd.2014.162
Wassef SN, Wemmie J, Johnson CP, Johnson H, Paulsen JS, Long JD, Magnotta VA
T1rho imaging in premanifest Huntington disease reveals changes associated with disease progression
Orsatti L, Speziale R, Orsale MV, Caretti F, Veneziano M, Zini M, Monteagudo E, Lyons K, Beconi M, Chan K, Herbst T, Toledo-Sherman L, Munoz-Sanjuan I, Bonelli F, Dominguez C
A single-run liquid chromatography mass spectrometry method to quantify neuroactive kynurenine pathway metabolites in rat plasma
Huang B, Lucas T, Kueppers C, Dong X, Krause M, Bepperling A, Buchner J, Voshol H, Weiss A, Gerrits B, Kochanek S
Scalable production in human cells and biochemical characterization of full-length normal and mutant huntingtin
Penrose SD, Stott AJ, Breccia P, Haughan AF, Burli RW, Jarvis RE, Dominguez C
Inter- and intramolecular annulation strategies to a cyclopentanone building block containing an all-carbon quaternary stereogenic center
Cheng HM, Chern Y, Chen IH, Liu CR, Li SH, Chun SJ, Rigo F, Bennett CF, Deng N, Feng Y, Lin CS, Yan YT, Cohen SN, Cheng TH
Effects on murine behavior and lifespan of selectively decreasing expression of mutant huntingtin allele by supt4h knockdown
Estrada-Sanchez AM, Burroughs CL, Cavaliere S, Barton SJ, Chen S, Yang XW, Rebec GV
Cortical efferents lacking mutant huntingtin improve striatal neuronal activity and behavior in a conditional mouse model of Huntington`s disease
Sturrock A, Laule C, Wyper K, Milner RA, Decolongon J, Dar Santos R, Coleman AJ, Carter K, Creighton S, Bechtel N, Bohlen S, Reilmann R, Johnson HJ, Hayden MR, Tabrizi SJ, Mackay AL, Leavitt BR
A longitudinal study of magnetic resonance spectroscopy Huntington`s disease biomarkers
Cao Y, Bartolomé-Martín D, Rotem N, Rozas C, Dellal SS, Chacon MA, Kadriu B, Gulinello M, Khodakhah K, Faber DS
Rescue of homeostatic regulation of striatal excitability and locomotor activity in a mouse model of Huntington's disease
Toledo-Sherman LM, Prime ME, Mrzljak L, Beconi MG, Beresford A, Brookfield FA, Brown CJ, Cardaun I, Courtney SM, Dijkman U, Hamelin-Flegg E, Johnson PD, Kempf V, Lyons K, Matthews K, Mitchell WL, O`Connell C, Pena P, Powell K, Rassoulpour A, Reed L, Reindl W, Selvaratnam S, Friley WW, Weddell DA, Went NE, Wheelan P, Winkler C, Winkler D, Wityak J, Yarnold CJ, Yates D, Munoz-Sanjuan I, Dominguez C
Development of a series of aryl pyrimidine kynurenine monooxygenase inhibitors as potential therapeutic agents for the treatment of Huntington`s disease
Poudel GR, Stout JC, Dominguez DJ F, Churchyard A, Chua P, Egan GF, Georgiou-Karistianis N
Longitudinal change in white matter microstructure in Huntington`s disease: The IMAGE-HD study
Dietz KN, Di Stefano L, Maher RC, Zhu H, Macdonald ME, Gusella JF, Walker JA
The Drosophila Huntington`s disease gene ortholog dhtt influences chromatin regulation during development
Nagy D, Tingley FD 3rd, Stoiljkovic M, Hajós M
Application of neurophysiological biomarkers for Huntington's disease: evaluating a phosphodiesterase 9A inhibitor
Curtin PC, Farrar AM, Oakeshott S, Sutphen J, Berger J, Mazzella M, Cox K, He D, Alosio W, Park LC, Howland D, Brunner D
Cognitive training at a young age attenuates deficits in the zQ175 mouse model of HD
Alterman JF, Hall LM, Coles AH, Hassler MR, Didiot MC, Chase K, Abraham J, Sottosanti E, Johnson E, Sapp E, Osborn MF, Difiglia M, Aronin N, Khvorova A
Hydrophobically modified siRNAs silence huntingtin mRNA in primary neurons and mouse brain
Carroll JB, Bates GP, Steffan J, Saft C, Tabrizi SJ
Treating the whole body in Huntington`s disease
The Lancet Neurology
January 1, 2015
14 (11) :1135-1142
14 (11) :1135-1142
PMID: 26466780
Oosterloo M, Van Belzen MJ, Bijlsma EK, Roos RA
Is there convincing evidence that intermediate repeats in the HTT gene cause Huntington`s disease?
Wood NI, Morton AJ
Social behaviour is impaired in the R6/2 mouse model of Huntington's disease
Reilmann R, Lippross V, Holzner E, Gigengack F, Bohlen S, Kugel H, Deppe M, Osada N, Lucke M, Riess O, Nguyen HP, Von Horsten S, Schafers K, Schafers M, Jacobs AH, Hermann S
FDG uPET fails to detect a disease-specific phenotype in rats transgenic for Huntington's disease
Musso M, Westervelt HJ, Long JD, Morgan E, Woods SP, Smith MM, Lu W, Paulsen JS, Predict-HD Investigators of the Huntington Study Group
Intra-individual variability in prodromal Huntington disease and its relationship to genetic burden
Carroll JB, Deik A, Fossale E, Weston RM, Guide JR, Arjomand J, Kwak S, Clish CB, MacDonald ME
HdhQ111 mice exhibit tissue specific metabolite profiles that include striatal lipid accumulation
Odish OF, Caeyenberghs K, Hosseini H, van den Bogaard SJ, Roos RA, Leemans A
Dynamics of the connectome in Huntington`s disease: A longitudinal diffusion MRI study
Grondin R, Ge P, Chen Q, Sutherland JE, Zhang Z, Gash DM, Stiles DK, Stewart GR, Sah DW, Kaemmerer WF
Onset time and durability of Huntingtin suppression in Rhesus putamen after direct infusion of Antihuntingtin siRNA
Mol Ther Nucleic Acids
January 1, 2015
4 :e245
4 :e245
PMID: 26125484
PMCID: PMC4561652
DOI: 10.1038/mtna.2015.20
Naseri NN, Xu H, Bonica J, Vonsattel JP, Cortes EP, Park LC, Arjomand J, Gibson GE
Abnormalities in the tricarboxylic Acid cycle in Huntington disease and in a Huntington disease mouse model
Carty N, Berson N, Tillack K, Thiede C, Scholz D, Kottig K, Sedaghat Y, Gabrysiak C, Yohrling G, von der Kammer H, Ebneth A, Mack V, Munoz-Sanjuan I, Kwak S
Characterization of HTT inclusion size, location, and timing in the zQ175 mouse model of Huntingtons disease: an in vivo high-content imaging study
Callaghan J, Stopford C, Arran N, Boisse MF, Coleman A, Santos RD, Dumas EM, Hart EP, Justo D, Owen G, Read J, Say MJ, Durr A, Leavitt BR, Roos RA, Tabrizi SJ, Bachoud-Levi AC, Bourdet C, van Duijn E, Craufurd D
Reliability and factor structure of the Short Problem Behaviors Assessment for Huntington`s disease (PBA-s) in the TRACK-HD and REGISTRY studies
J Neuropsychiatry Clin Neurosci
January 1, 2015
27 (1) :59-64
27 (1) :59-64
PMID: 25716488
Gabery S, Georgiou-Karistianis N, Lundh SH, Cheong RY, Churchyard A, Chua P, Stout JC, Egan GF, Kirik D, Petersen A
Volumetric analysis of the hypothalamus in Huntington Disease using 3T MRI: the IMAGE-HD Study
Cummings J, Mintzer J, Brodaty H, Sano M, Banerjee S, Devanand DP, Gauthier S, Howard R, Lanctot K, Lyketsos CG, Peskind E, Porsteinsson AP, Reich E, Sampaio C, Steffens D, Wortmann M, Zhong K, International Psychogeriatric Association
Agitation in cognitive disorders: International Psychogeriatric Association provisional consensus clinical and research definition
Odish OF, van den Berg-Huysmans AA, van den Bogaard SJ, Dumas EM, Hart EP, Rombouts SA, van der Grond J, Roos RA, Track-Hd Investigator Group
Longitudinal resting state fMRI analysis in healthy controls and premanifest Huntington`s disease gene carriers: a three-year follow-up study
Mrzljak L, Munoz-Sanjuan I
Therapeutic strategies for Huntington`s Disease
Poudel GR, Stout JC, Dominguez DJ, Gray MA, Salmon L, Churchyard A, Chua P, Borowsky B, Egan GF, Georgiou-Karistianis N
Functional changes during working memory in Huntington`s disease: 30-month longitudinal data from the IMAGE-HD study