Listed here are over 1,100 publications that describe some of the research funded (in whole or in part) by CHDI Foundation. You can also view just the subset of publications that have CHDI staff as authors.
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Title
Journal
Bustamante MB, Ansaloni A, Pedersen JF, Azzollini L, Cariulo C, Wang ZM, Petricca L, Verani M, Puglisi F, Park H, Lashuel H, Caricasole A
Detection of huntingtin exon 1 phosphorylation by Phos-Tag SDS-PAGE: Predominant phosphorylation on threonine 3 and regulation by IKKbeta
Biochem Biophys Res Commun
August 7, 2015
463 (4) :1317-22
463 (4) :1317-22
PMID: 26106822
Kloppel S, Gregory S, Scheller E, Minkova L, Razi A, Durr A, Roos RAC, Leavitt BR, Papoutsi M, Landwehrmeyer GB, Reilmann R, Borowsky B, Johnson H, Mills JA, Owen G, Stout J, Scahill RI, Long JD, Rees G, Tabrizi SJ
Compensation in preclinical Huntington`s disease: evidence from the Track-On HD study
Arrowsmith CH, Audia JE, Austin C, Baell J, Bennett J, Blagg J, Bountra C, Brennan PE, Brown PJ, Bunnage ME, Buser-Doepner C, Campbell RM, Carter AJ, Cohen P, Copeland RA, Cravatt B, Dahlin JL, Dhanak D, Edwards AM, Frye SV, Gray N, Grimshaw CE, Hepworth D, Howe T, Huber KV, Jin J, Knapp S, Kotz JD, Kruger RG, Lowe D, Mader MM, Marsden B, Mueller-Fahrnow A, Muller S, O`Hagan RC, Overington JP, Owen DR,…Zuercher WJ
The promise and peril of chemical probes
Harrington DL, Rubinov M, Durgerian S, Mourany L, Reece C, Koenig K, Bullmore E, Long JD, Paulsen JS, Predict-Hd investigators of the Huntington Study Group, Rao SM
Network topology and functional connectivity disturbances precede the onset of Huntington`s disease
Plotkin JL, Surmeier DJ
Corticostriatal synaptic adaptations in Huntington`s disease
O`Brien R, DeGiacomo F, Holcomb J, Bonner A, Ring KL, Zhang N, Zafar K, Weiss A, Lager B, Schilling B, Gibson BW, Chen S, Kwak S, Ellerby LM
Integration-independent transgenic Huntington disease fragment mouse models reveal distinct phenotypes and life span in vivo
GeM-HD Consortium
Identification of genetic factors that modify clinical onset of Huntington`s disease
Sun X, Li PP, Zhu S, Cohen R, Marque LO, Ross CA, Pulst SM, Chan HY, Margolis RL, Rudnicki DD
Nuclear retention of full-length HTT RNA is mediated by splicing factors MBNL1 and U2AF65
Khakh BS, Sofroniew MV
Diversity of astrocyte functions and phenotypes in neural circuits
Achour M, Le Gras S, Keime C, Parmentier F, Lejeune FX, Boutillier AL, Néri C, Davidson I, Merienne K
Neuronal identity genes regulated by super-enhancers are preferentially down-regulated in the striatum of Huntington's disease mice
Friedman A, Homma D, Gibb LG, Amemori K, Rubin SJ, Hood AS, Riad MH, Graybiel AM
A corticostriatal path targeting striosomes controls decision-making under conflict
Becanovic K, Norremolle A, Neal SJ, Kay C, Collins JA, Arenillas D, Lilja T, Gaudenzi G, Manoharan S, Doty CN, Beck J, Lahiri N, Portales-Casamar E, Warby SC, Connolly C, De Souza RA, Registry Investigators of the European Huntington`s Disease Network, Tabrizi SJ, Hermanson O, Langbehn DR, Hayden MR, Wasserman WW, Leavitt BR
A SNP in the HTT promoter alters NF-kappaB binding and is a bidirectional genetic modifier of Huntington disease
Odish OF, Leemans A, Reijntjes RH, van den Bogaard SJ, Dumas EM, Wolterbeek R, Tax CM, Kuijf HJ, Vincken KL, van der Grond J, Roos RA
Microstructural brain abnormalities in Huntington`s disease: A two-year follow-up
Dominguez JF, Ng AC, Poudel G, Stout JC, Churchyard A, Chua P, Egan GF, Georgiou-Karistianis N
Iron accumulation in the basal ganglia in Huntington`s disease: cross-sectional data from the IMAGE-HD study
J Neurol Neurosurg Psychiatry
May 7, 2015
87 (5) :545-9
87 (5) :545-9
PMID: 25952334
Wild EJ, Boggio R, Langbehn D, Robertson N, Haider S, Miller JR, Zetterberg H, Leavitt BR, Kuhn R, Tabrizi SJ, Macdonald D, Weiss A
Quantification of mutant huntingtin protein in cerebrospinal fluid from Huntington`s disease patients
Novak MJ, Seunarine KK, Gibbard CR, McColgan P, Draganski B, Friston K, Clark CA, Tabrizi SJ
Basal ganglia-cortical structural connectivity in Huntington`s disease
Jin J, Peng Q, Hou Z, Jiang M, Wang X, Langseth AJ, Tao M, Barker PB, Mori S, Bergles DE, Ross CA, Detloff PJ, Zhang J, Duan W
Early white matter abnormalities, progressive brain pathology and motor deficits in a novel knock-in mouse model of Huntington`s disease
Biagioli M, Ferrari F, Mendenhall EM, Zhang Y, Erdin S, Vijayvargia R, Vallabh SM, Solomos N, Manavalan P, Ragavendran A, Ozsolak F, Lee JM, Talkowski ME, Gusella JF, Macdonald ME, Park PJ, Seong IS
Htt CAG repeat expansion confers pleiotropic gains of mutant huntingtin function in chromatin regulation
Wityak J, McGee KF, Conlon MP, Song RH, Duffy BC, Clayton B, Lynch M, Wang G, Freeman E, Haber J, Kitchen DB, Manning DD, Ismail J, Khmelnitsky Y, Michels P, Webster J, Irigoyen M, Luche M, Hultman M, Bai M, Kuok ID, Newell R, Lamers M, Leonard P, Yates D, Matthews K, Ongeri L, Clifton S, Mead T, Deupree S, Wheelan P, Lyons K, Wilson C, Kiselyov A, Toledo-Sherman L, Beconi M, Muñoz-Sanjuan I, Bard J, Dominguez C
Lead optimization toward proof-of-concept tools for Huntington's disease within a 4-(1H-pyrazol-4-yl) pyrimidine class of pan-JNK inhibitors
Larson E, Fyfe I, Morton AJ, Monckton DG
Age-, tissue- and length-dependent bidirectional somatic CAG•CTG repeat instability in an allelic series of R6/2 Huntington disease mice
Sanders SS, Hayden MR
Aberrant palmitoylation in Huntington disease
Hering T, Birth N, Taanman JW, Orth M
Selective striatal mtDNA depletion in end-stage Huntington`s disease R6/2 mice
Khakh BS, McCarthy KD
Astrocyte calcium signaling: from observations to functions and the challenges therein
Cold Spring Harb Perspect Biol
April 1, 2015
7 (4) :a020404
7 (4) :a020404
PMID: 25605709
Valenza M, Marullo M, Di Paolo E, Cesana E, Zuccato C, Biella G, Cattaneo E
Disruption of astrocyte-neuron cholesterol cross talk affects neuronal function in Huntington`s disease
Cell Death Differ
April 1, 2015
22 (4) :690-702
22 (4) :690-702
PMID: 25301063
PMCID: 4356339
DOI: 10.1038/cdd.2014.162
Wassef SN, Wemmie J, Johnson CP, Johnson H, Paulsen JS, Long JD, Magnotta VA
T1rho imaging in premanifest Huntington disease reveals changes associated with disease progression
Orsatti L, Speziale R, Orsale MV, Caretti F, Veneziano M, Zini M, Monteagudo E, Lyons K, Beconi M, Chan K, Herbst T, Toledo-Sherman L, Munoz-Sanjuan I, Bonelli F, Dominguez C
A single-run liquid chromatography mass spectrometry method to quantify neuroactive kynurenine pathway metabolites in rat plasma
Huang B, Lucas T, Kueppers C, Dong X, Krause M, Bepperling A, Buchner J, Voshol H, Weiss A, Gerrits B, Kochanek S
Scalable production in human cells and biochemical characterization of full-length normal and mutant huntingtin
Penrose SD, Stott AJ, Breccia P, Haughan AF, Burli RW, Jarvis RE, Dominguez C
Inter- and intramolecular annulation strategies to a cyclopentanone building block containing an all-carbon quaternary stereogenic center
Cheng HM, Chern Y, Chen IH, Liu CR, Li SH, Chun SJ, Rigo F, Bennett CF, Deng N, Feng Y, Lin CS, Yan YT, Cohen SN, Cheng TH
Effects on murine behavior and lifespan of selectively decreasing expression of mutant huntingtin allele by supt4h knockdown
Estrada-Sanchez AM, Burroughs CL, Cavaliere S, Barton SJ, Chen S, Yang XW, Rebec GV
Cortical efferents lacking mutant huntingtin improve striatal neuronal activity and behavior in a conditional mouse model of Huntington`s disease
Sturrock A, Laule C, Wyper K, Milner RA, Decolongon J, Dar Santos R, Coleman AJ, Carter K, Creighton S, Bechtel N, Bohlen S, Reilmann R, Johnson HJ, Hayden MR, Tabrizi SJ, Mackay AL, Leavitt BR
A longitudinal study of magnetic resonance spectroscopy Huntington`s disease biomarkers
Cao Y, Bartolomé-Martín D, Rotem N, Rozas C, Dellal SS, Chacon MA, Kadriu B, Gulinello M, Khodakhah K, Faber DS
Rescue of homeostatic regulation of striatal excitability and locomotor activity in a mouse model of Huntington's disease
Toledo-Sherman LM, Prime ME, Mrzljak L, Beconi MG, Beresford A, Brookfield FA, Brown CJ, Cardaun I, Courtney SM, Dijkman U, Hamelin-Flegg E, Johnson PD, Kempf V, Lyons K, Matthews K, Mitchell WL, O`Connell C, Pena P, Powell K, Rassoulpour A, Reed L, Reindl W, Selvaratnam S, Friley WW, Weddell DA, Went NE, Wheelan P, Winkler C, Winkler D, Wityak J, Yarnold CJ, Yates D, Munoz-Sanjuan I, Dominguez C
Development of a series of aryl pyrimidine kynurenine monooxygenase inhibitors as potential therapeutic agents for the treatment of Huntington`s disease
Poudel GR, Stout JC, Dominguez DJ F, Churchyard A, Chua P, Egan GF, Georgiou-Karistianis N
Longitudinal change in white matter microstructure in Huntington`s disease: The IMAGE-HD study
Dietz KN, Di Stefano L, Maher RC, Zhu H, Macdonald ME, Gusella JF, Walker JA
The Drosophila Huntington`s disease gene ortholog dhtt influences chromatin regulation during development
Nagy D, Tingley FD 3rd, Stoiljkovic M, Hajós M
Application of neurophysiological biomarkers for Huntington's disease: evaluating a phosphodiesterase 9A inhibitor
Curtin PC, Farrar AM, Oakeshott S, Sutphen J, Berger J, Mazzella M, Cox K, He D, Alosio W, Park LC, Howland D, Brunner D
Cognitive training at a young age attenuates deficits in the zQ175 mouse model of HD
Alterman JF, Hall LM, Coles AH, Hassler MR, Didiot MC, Chase K, Abraham J, Sottosanti E, Johnson E, Sapp E, Osborn MF, Difiglia M, Aronin N, Khvorova A
Hydrophobically modified siRNAs silence huntingtin mRNA in primary neurons and mouse brain
Carroll JB, Bates GP, Steffan J, Saft C, Tabrizi SJ
Treating the whole body in Huntington`s disease
The Lancet Neurology
January 1, 2015
14 (11) :1135-1142
14 (11) :1135-1142
PMID: 26466780
Oosterloo M, Van Belzen MJ, Bijlsma EK, Roos RA
Is there convincing evidence that intermediate repeats in the HTT gene cause Huntington`s disease?