CHDI
Listed here are over 1,075 publications that describe some of the research funded (in whole or in part) by CHDI Foundation. You can also view just the subset of publications that have CHDI staff as authors.
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Title
Journal
Orsatti L, Speziale R, Orsale MV, Caretti F, Veneziano M, Zini M, Monteagudo E, Lyons K, Beconi M, Chan K, Herbst T, Toledo-Sherman L, Munoz-Sanjuan I, Bonelli F, Dominguez C
A single-run liquid chromatography mass spectrometry method to quantify neuroactive kynurenine pathway metabolites in rat plasma
Huang B, Lucas T, Kueppers C, Dong X, Krause M, Bepperling A, Buchner J, Voshol H, Weiss A, Gerrits B, Kochanek S
Scalable production in human cells and biochemical characterization of full-length normal and mutant huntingtin
Penrose SD, Stott AJ, Breccia P, Haughan AF, Burli RW, Jarvis RE, Dominguez C
Inter- and intramolecular annulation strategies to a cyclopentanone building block containing an all-carbon quaternary stereogenic center
Cheng HM, Chern Y, Chen IH, Liu CR, Li SH, Chun SJ, Rigo F, Bennett CF, Deng N, Feng Y, Lin CS, Yan YT, Cohen SN, Cheng TH
Effects on murine behavior and lifespan of selectively decreasing expression of mutant huntingtin allele by supt4h knockdown
Estrada-Sanchez AM, Burroughs CL, Cavaliere S, Barton SJ, Chen S, Yang XW, Rebec GV
Cortical efferents lacking mutant huntingtin improve striatal neuronal activity and behavior in a conditional mouse model of Huntington`s disease
Sturrock A, Laule C, Wyper K, Milner RA, Decolongon J, Dar Santos R, Coleman AJ, Carter K, Creighton S, Bechtel N, Bohlen S, Reilmann R, Johnson HJ, Hayden MR, Tabrizi SJ, Mackay AL, Leavitt BR
A longitudinal study of magnetic resonance spectroscopy Huntington`s disease biomarkers
Cao Y, Bartolomé-Martín D, Rotem N, Rozas C, Dellal SS, Chacon MA, Kadriu B, Gulinello M, Khodakhah K, Faber DS
Rescue of homeostatic regulation of striatal excitability and locomotor activity in a mouse model of Huntington's disease
Toledo-Sherman LM, Prime ME, Mrzljak L, Beconi MG, Beresford A, Brookfield FA, Brown CJ, Cardaun I, Courtney SM, Dijkman U, Hamelin-Flegg E, Johnson PD, Kempf V, Lyons K, Matthews K, Mitchell WL, O`Connell C, Pena P, Powell K, Rassoulpour A, Reed L, Reindl W, Selvaratnam S, Friley WW, Weddell DA, Went NE, Wheelan P, Winkler C, Winkler D, Wityak J, Yarnold CJ, Yates D, Munoz-Sanjuan I, Dominguez C
Development of a series of aryl pyrimidine kynurenine monooxygenase inhibitors as potential therapeutic agents for the treatment of Huntington`s disease
Poudel GR, Stout JC, Dominguez DJ F, Churchyard A, Chua P, Egan GF, Georgiou-Karistianis N
Longitudinal change in white matter microstructure in Huntington`s disease: The IMAGE-HD study
Dietz KN, Di Stefano L, Maher RC, Zhu H, Macdonald ME, Gusella JF, Walker JA
The Drosophila Huntington`s disease gene ortholog dhtt influences chromatin regulation during development
Nagy D, Tingley FD 3rd, Stoiljkovic M, Hajós M
Application of neurophysiological biomarkers for Huntington's disease: evaluating a phosphodiesterase 9A inhibitor
Curtin PC, Farrar AM, Oakeshott S, Sutphen J, Berger J, Mazzella M, Cox K, He D, Alosio W, Park LC, Howland D, Brunner D
Cognitive training at a young age attenuates deficits in the zQ175 mouse model of HD
Alterman JF, Hall LM, Coles AH, Hassler MR, Didiot MC, Chase K, Abraham J, Sottosanti E, Johnson E, Sapp E, Osborn MF, Difiglia M, Aronin N, Khvorova A
Hydrophobically modified siRNAs silence huntingtin mRNA in primary neurons and mouse brain
Carroll JB, Bates GP, Steffan J, Saft C, Tabrizi SJ
Treating the whole body in Huntington`s disease
The Lancet Neurology
January 1, 2015
14 (11) :1135-1142
14 (11) :1135-1142
PMID: 26466780
Oosterloo M, Van Belzen MJ, Bijlsma EK, Roos RA
Is there convincing evidence that intermediate repeats in the HTT gene cause Huntington`s disease?
Wood NI, Morton AJ
Social behaviour is impaired in the R6/2 mouse model of Huntington's disease
Reilmann R, Lippross V, Holzner E, Gigengack F, Bohlen S, Kugel H, Deppe M, Osada N, Lucke M, Riess O, Nguyen HP, Von Horsten S, Schafers K, Schafers M, Jacobs AH, Hermann S
FDG uPET fails to detect a disease-specific phenotype in rats transgenic for Huntington's disease
Musso M, Westervelt HJ, Long JD, Morgan E, Woods SP, Smith MM, Lu W, Paulsen JS, Predict-HD Investigators of the Huntington Study Group
Intra-individual variability in prodromal Huntington disease and its relationship to genetic burden
Carroll JB, Deik A, Fossale E, Weston RM, Guide JR, Arjomand J, Kwak S, Clish CB, MacDonald ME
HdhQ111 mice exhibit tissue specific metabolite profiles that include striatal lipid accumulation
Odish OF, Caeyenberghs K, Hosseini H, van den Bogaard SJ, Roos RA, Leemans A
Dynamics of the connectome in Huntington`s disease: A longitudinal diffusion MRI study
Grondin R, Ge P, Chen Q, Sutherland JE, Zhang Z, Gash DM, Stiles DK, Stewart GR, Sah DW, Kaemmerer WF
Onset time and durability of Huntingtin suppression in Rhesus putamen after direct infusion of Antihuntingtin siRNA
Mol Ther Nucleic Acids
January 1, 2015
4 :e245
4 :e245
PMID: 26125484
PMCID: PMC4561652
DOI: 10.1038/mtna.2015.20
Naseri NN, Xu H, Bonica J, Vonsattel JP, Cortes EP, Park LC, Arjomand J, Gibson GE
Abnormalities in the tricarboxylic Acid cycle in Huntington disease and in a Huntington disease mouse model
Carty N, Berson N, Tillack K, Thiede C, Scholz D, Kottig K, Sedaghat Y, Gabrysiak C, Yohrling G, von der Kammer H, Ebneth A, Mack V, Munoz-Sanjuan I, Kwak S
Characterization of HTT inclusion size, location, and timing in the zQ175 mouse model of Huntingtons disease: an in vivo high-content imaging study
Callaghan J, Stopford C, Arran N, Boisse MF, Coleman A, Santos RD, Dumas EM, Hart EP, Justo D, Owen G, Read J, Say MJ, Durr A, Leavitt BR, Roos RA, Tabrizi SJ, Bachoud-Levi AC, Bourdet C, van Duijn E, Craufurd D
Reliability and factor structure of the Short Problem Behaviors Assessment for Huntington`s disease (PBA-s) in the TRACK-HD and REGISTRY studies
J Neuropsychiatry Clin Neurosci
January 1, 2015
27 (1) :59-64
27 (1) :59-64
PMID: 25716488
Gabery S, Georgiou-Karistianis N, Lundh SH, Cheong RY, Churchyard A, Chua P, Stout JC, Egan GF, Kirik D, Petersen A
Volumetric analysis of the hypothalamus in Huntington Disease using 3T MRI: the IMAGE-HD Study
Cummings J, Mintzer J, Brodaty H, Sano M, Banerjee S, Devanand DP, Gauthier S, Howard R, Lanctot K, Lyketsos CG, Peskind E, Porsteinsson AP, Reich E, Sampaio C, Steffens D, Wortmann M, Zhong K, International Psychogeriatric Association
Agitation in cognitive disorders: International Psychogeriatric Association provisional consensus clinical and research definition
Odish OF, van den Berg-Huysmans AA, van den Bogaard SJ, Dumas EM, Hart EP, Rombouts SA, van der Grond J, Roos RA, Track-Hd Investigator Group
Longitudinal resting state fMRI analysis in healthy controls and premanifest Huntington`s disease gene carriers: a three-year follow-up study
Mrzljak L, Munoz-Sanjuan I
Therapeutic strategies for Huntington`s Disease
Poudel GR, Stout JC, Dominguez DJ, Gray MA, Salmon L, Churchyard A, Chua P, Borowsky B, Egan GF, Georgiou-Karistianis N
Functional changes during working memory in Huntington`s disease: 30-month longitudinal data from the IMAGE-HD study
Lu XH, Mattis VB, Wang N, Al-Ramahi I, van den Berg N, Fratantoni SA, Waldvogel H, Greiner E, Osmand A, Elzein K, Xiao J, Dijkstra S, de Pril R, Vinters HV, Faull R, Signer E, Kwak S, Marugan JJ, Botas J, Fischer DF, Svendsen CN, Munoz-Sanjuan I, Yang XW
Targeting ATM ameliorates mutant Huntingtin toxicity in cell and animal models of Huntington's disease
Fodale V, Kegulian NC, Verani M, Cariulo C, Azzollini L, Petricca L, Daldin M, Boggio R, Padova A, Kuhn R, Pacifici R, Macdonald D, Schoenfeld RC, Park H, Isas JM, Langen R, Weiss A, Caricasole A
Polyglutamine- and temperature-dependent conformational rigidity in mutant huntingtin revealed by immunoassays and circular dichroism spectroscopy
Paulsen JS, Long JD, Ross CA, Harrington DL, Erwin CJ, Williams JK, Westervelt HJ, Johnson HJ, Aylward EH, Zhang Y, Bockholt HJ, Barker RA, Predict-Hd Investigators, Coordinators of the Huntington Study Group
Prediction of manifest Huntington`s disease with clinical and imaging measures: a prospective observational study
Ochaba J, Lukacsovich T, Csikos G, Zheng S, Margulis J, Salazar L, Mao K, Lau AL, Yeung SY, Humbert S, Saudou F, Klionsky DJ, Finkbeiner S, Zeitlin SO, Marsh JL, Housman DE, Thompson LM, Steffan JS
Potential function for the Huntingtin protein as a scaffold for selective autophagy
Rees EM, Farmer R, Cole JH, Haider S, Durr A, Landwehrmeyer B, Scahill RI, Tabrizi SJ, Hobbs NZ
Cerebellar abnormalities in Huntington's disease: a role in motor and psychiatric impairment?
van Wamelen DJ, Aziz NA, Roos RA, Swaab DF
Hypothalamic alterations in Huntington's disease patients: comparison with genetic rodent models
Rees EM, Farmer R, Cole JH, Henley SM, Sprengelmeyer R, Frost C, Scahill RI, Hobbs NZ, Tabrizi SJ
Inconsistent emotion recognition deficits across stimulus modalities in Huntington׳s disease
Neuropsychologia
November 1, 2014
64 :99-104
64 :99-104
PMID: 25250707
Yao J, Ong SE, Bajjalieh S
Huntingtin is associated with cytomatrix proteins at the presynaptic terminal
Deng YP, Wong T, Wan JY, Reiner A
Differential loss of thalamostriatal and corticostriatal input to striatal projection neuron types prior to overt motor symptoms in the Q140 knock-in mouse model of Huntington's disease
Kalliolia E, Silajdžić E, Nambron R, Hill NR, Doshi A, Frost C, Watt H, Hindmarsh P, Björkqvist M, Warner TT
Plasma melatonin is reduced in Huntington's disease
Brito V, Giralt A, Enriquez-Barreto L, Puigdellívol M, Suelves N, Zamora-Moratalla A, Ballesteros JJ, Martín ED, Dominguez-Iturza N, Morales M, Alberch J, Ginés S
Neurotrophin receptor p75(NTR) mediates Huntington's disease-associated synaptic and memory dysfunction