Science Director –Translational Biomarkers

Job Location

The position will be based in Princeton, N.J. with occasional travel to New York City and Los Angeles.

Job Reports To

Vice President, Drug Discovery Genotype & Phenotype Unit

Job Description

Translational Biomarker Scientist with role and responsibilities to lead and contribute to the discovery, exploration, and validation of candidate biomarkers to support Human Genetic based therapeutic candidates This position involves collaborating with internal CHDI scientists and external academics, and contract research organization collaborators to accelerate new therapies for Huntington’s disease (HD).

Job Responsibilities:

  • Contribute to evaluation of candidate targets emerging from human genetic studies that identify modifiers of HD for therapeutic modulation
  • Contribute to developing strategies and their implementation to investigate and advance understanding of mechanism of action of candidate human genetic based targets
  • Lead the exploration of relevant biological contexts for the discovery of target engagement, pharmacodynamic, and efficacy biomarkers with a priority focus on DNA mismatch repair proteins and biomarkers of triplet nucleotide repeat somatic instability.
  • Collaborate with Platform teams to identify and deliver reagents to support biomarker discovery and validation (Genetically modified animal models, protein production, antibody production, )
  • Collaborate with Clinical Unit in exploration of Biomarker Discovery using the HD-ENROLL Platform
  • Lead and collaborate with teams to conceptualize, implement, validate, and integrate translational target engagement and pharmacodynamic biomarker discovery into an efficient flow scheme for candidates to human genetics based therapeutic programs across range of modalities (small molecule, RNAi, CRISPR)
  • Oversee the development of standard operating protocols for assays and for biomarker data qualification and registration
  • Review and approve detailed reports for each project and campaign in area of responsibility
  • Communicate results in presentations at scientific meetings and by co-authoring publications

Requirements:

The candidate of choice will have:

  • An MD and/or PhD in Pharmacology, Biochemistry, Molecular/Cell Biology (‘omics), or (Patho)Physiology
  • Proven track record demonstrating rigor and evidence of collaboration with integrated project and clinical biomarker teams.
  • >5years of experience in the biopharmaceutical sector, with an emphasis on translational biomarkers.
  • Experience of successfully validating candidate biomarkers from non-clinical to the clinical setting
  • Experience in developing and qualifying standard operating protocols for biomarker assays
  • Experience with establishing target engagement and pharmacodynamic endpoints and forward and back translation between humans and animal models.
  • Demonstrated track record of contributing to drug discovery project teams and partnering with Medicinal Chemistry.
  • Significant experience leading targets & projects through sanctioning milestones,
  • Expertise in rigorous data analyses and interpretation
  • Excellent written and oral communication skills
  • Strong ability to both lead and be a team player in an interdisciplinary team-oriented environment

Preferred Skills:

An ideal candidate would also have:

  • Familiarity with industry standard quantitative biology tools, technologies, and vendors.
  • Experience in managing external contract research organization collaborations
  • Experience in biomarker development in the context of DNA Repair and Handling pathways (e.g. oncology, neuroscience)
  • Expertise in prosecuting nucleic acid analytes as candidate biomarkers, including familiarity with exosomes
  • Expertise in interrogating a breadth of accessible tissues and biofluids
  • Experience in ’omics analytes and classifier discovery
  • Experience in multi-modal biomarker integration (“wet” and imaging)
  • Knowledge of biostatistics
  • Familiarity and/or experience with integrating biomarkers in clinical trials
  • Familiarity/Experience with CLIA certification

Send CV’s to jobs@chdifoundation.org