Science Director, In Vivo Pharmacology

Job Location

Princeton Office

Job Reports To

VP Biology

Job Description

In Vivo Pharmacologist will be responsible for the design and oversight of target and therapeutic agent evaluation in multiple animal models (rodents and large animals including non-human primates) relevant to Huntington’s disease (HD) research. The Scientific Director will also have oversight responsibilities for the in life studies of drug discovery and gene therapy campaigns for the treatment of Huntington’s disease.

The position involves collaborating with internal scientific directors and program managers at CHDI and the management of a larger “virtual” team of external collaborators (at contract research laboratories and academic institutions) to discover and develop therapies for Huntington’s dise

In Vivo Pharmacologist will be responsible for the design and oversight of target and therapeutic agent evaluation in multiple animal models (rodents and large animals including non-human primates) relevant to Huntington’s disease (HD) research. The Scientific Director will also have oversight responsibilities for the in life studies of drug discovery and gene therapy campaigns for the treatment of Huntington’s disease.
The responsibilities include:

  • Managing external CROs for testing candidate therapeutic agents for Huntington’s disease in relevant rodent models, large farm animals and nonhuman primates
  • Working closely with academic and industrial collaborators in areas relevant to disease modeling in animal models, including non-human primates.
  • Developing and managing the implementation of molecular, histological and behavioral endpoints relevant to disease modification studies in HD.
  • Working closely with other scientific directors for target biology validation, pharmacodynamic target engagement, pathway modulation and assessment of disease modification using various molecular, behavioral and imaging endpoints in relevant animal models.
  • Working closely with DMPK colleagues.
  • Designing and implementing therapeutic testing strategies for the various drug discovery and gene therapy programs.
  • Selecting and managing external vendors to providing relevant services and qualification of data and reports.
  • Writing peer-review publications and presenting internally and at relevant conferences.

Requirements:

The candidate of choice will have:

  • A PhD in Neuroscience or Pharmacology
  • 5 or more years of experience in the biopharmaceutical sector, with an emphasis on Neuroscience drug discovery.
  • A detailed theoretical and practical knowledge of pharmacology.
  • Experience in the oversight and management of contract research organizations
  • Knowledge and experience using genetically modified animals in drug discovery in the areas relevant to neurodegeneration
  • Experience with small molecule and large molecule (e.g. antibodies and/or viruses/gene therapy) drug discovery and in vivo
  • Experience with establishing pharmacodynamic endpoints for mechanistic engagement, in support of therapeutic drug testing.
  • Experience working with large animals, particularly nonhuman primates, in drug discovery, with experience in a range of phenotypes including cognition, fine motor control and/or basal ganglia relevant behaviors.
  • Evidence of experience leading programs, influencing skills, team-building, cross-disciplinary collaboration, and a deep understanding of the drug discovery process.
  • Demonstrated track record of being part of drug discovery project teams and partnering with Medicinal Chemistry/DMPK teams to successfully advance candidate therapeutics
  • Excellent written and oral communication skills.

Preferred Skills:

An ideal candidate might also have:

  • Experience and expertise in behavioral pharmacology
  • Experience and skills in pharmacological modeling
  • Experience in the development and qualification of biomarkers
  • Expertise in imaging technologies as applied to neuroscience
  • A publication record showing creative thinking as well as evidence of cross-functional team work.

Send CV to jobs@chdifoundation.org