Director, Clinical Neuroimaging Research

Director, Clinical Neuroimaging Research

Job Location

The position will be based in Princeton, N.J. with occasional travel to CHDI’s other offices and meeting with collaborators

Job Reports To

Vice President, Clinical Neuroimaging Research

Job Description

CHDI oversees a portfolio of projects aimed at understanding the natural progression of Huntington’s disease, developing the best biomarkers and endpoints for use in clinical trials, and working with external partners to develop and execute clinical development plans for novel therapeutics. Furthermore, CHDI has a large portfolio of scientific and preclinical projects, which generate a significant volume of data. The team engages a diverse array of partners to help manage this extensive portfolio, including academic institutions, government agencies, CROs, biotech and pharmaceutical companies.

Neuroimaging research is a major part of this strategy and we are seeking a highly motivated individual to contribute to the design, management and analysis of cutting edge clinical neuroimaging studies and neuroimaging analytics to further our understanding of Huntington’s disease pathogenic mechanisms and to develop neuroimaging based biomarkers for use as drug development tools. The individual will work closely with scientists, project managers and data managers at CHDI, and with the broader HD scientific community.  Using their extensive knowledge and experience, along with a collaborative approach, the successful candidate will help CHDI achieve its mission.

This individual will maintain excellent working relationships with collaborators both internal and external to CHDI. They will keep abreast of new developments in their field, as well as the regulatory environment required to implement clinical studies. 

The position offers involvement in a novel model of non-profit orphan disease drug discovery development and an entrepreneurial work environment with high impact.

Job Responsibilities

  • Plan and manage multimodal neuroimaging clinical research studies with academic/industrial collaborators and CRO’s
  • Provide medical/scientific input and drive/contribute to the creation of relevant clinical documents required for the implementation, monitoring and evaluation of clinical neuroimaging studies
  • Review data produced by project teams and ensure that studies are completed on time and within budget; monitor recruitment progress and data quality
  • Manage collaborative relationships with clinical investigators globally to ensure optimal interactions and timely execution of clinical studies
  • Contribute to translational activities linking Preclinical and Clinical workflow
  • Contribute to scientific strategy to achieve the goals of the Clinical Neuroimaging Research platform
  • Proactively contribute to ongoing scientific dialog for various Foundation programs
  • Work independently while leading the study teams and directing the work of team members
  • Manage fiscal performance of the studies and maintain close control of study costs


  • D. or MD in the field of nuclear medicine, neuroimaging, neurosciences with at least 5 years of direct experience in clinical research in pharma/biotech or academic settings
  • Practical experience with the application of multiple neuroimaging modalities including PET and MRI in the context of clinical research, drug discovery or translational sciences
  • Sophisticated understanding of neuroimaging pipeline analysis techniques and working knowledge of relevant neuroimaging software and data visualization tools
  • Experience in machine learning, neuroimaging analytics and interpretation of statistical modeling would be an advantage
  • Familiarity with radiopharmaceutical use and development
  • Demonstrated ability to effectively contribute to clinical protocol design, data interpretation, and review and reporting of results from clinical studies
  • Demonstrated knowledge of clinical trial components and support functions
  • Knowledge of FDA and ICH regulations regarding Good Clinical Practice (GCP)
  • CRO, contract management, and budgetary experience an advantage
  • Excellent interpersonal skills, and both written and oral communication skills
  • Flexible, well organized, with strong time management and multitasking skills
  • Ability to work in a matrix organization and cross-functionally identify and resolve issues
  • Preferred experience/background in neurodegenerative diseases

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