Director, Clinical and Translational Neuroimaging Research

Job Location

The position will be based in Princeton, N.J. with occasional travel to CHDI’s other offices in LA, NYC and our collaborators.

Job Reports To

This position will report to the Vice President, Clinical Neuroimaging Research and will support clinical and translational neuroimaging research for CHDI Foundation, Inc.

Job Description

Working within a matrix organization, the candidate will provide leadership and scientific innovation in the design and conduct of clinical and translational neuroimaging research studies to better understand the pathophysiology of HD and to develop biomarkers for use as drug development tools. White matter degeneration has critically emerged as a key factor in HD progression, therefore a specific focus on understanding and targeting white matter pathophysiology in HD is anticipated using both MRI and glial molecular and cellular methodologies. The candidate is therefore expected to have a strong background in both clinical experimental MRI and translational animal research. The individual will work closely with the Vice President, Translational Biology on all preclinical aspects, as part of an extended team of scientists working on HTT lowering therapeutic strategies other scientists at CHDI, our outside imaging collaborators and with the broader HD scientific community to advance HD clinical and translational research.

Responsibilities will include

  • Review and evaluate current and emerging MRI sequences, their application and processing to develop cutting edge MRI assessment protocols for analysis of change in white matter biology in both HD and HD animal models and their translatability.
  • Using existing MRI data to develop and implement post acquisition processing pipelines to monitor MRI data quality and support in depth interpretation of findings.
  • Establish collaborations with leading specialists in the field of clinical MRI measurement of white matter to further mechanistic understanding of white matter changes in HD subjects and controls.
  • Design, manage and contribute to multimodal neuroimaging clinical research studies with academic/industrial collaborators and CRO’s; in particular, those aspects that feature in depth measurement of changes in white matter using MRI.
  • Provide scientific input and drive/contribute to the creation of relevant clinical documents required for the implementation and evaluation of such clinical neuroimaging studies, including study concepts, protocol, data analysis plans, investigator brochure, ICF, CSRs etc.
  • Lead translational activities linking pre-clinical and clinical workflow for white matter assessment and oligodendroglial pathophysiology within the Foundation.
  • Explore MRI-based techniques as biomarkers of progression and in the context of HTT lowering therapeutic strategies using animal models of HD.
  • Evaluate the role of HTT in white matter and oligodendrocyte alterations in animal models of HD, as part of a larger team of physiologists and HTT lowering scientists, using genetic, molecular, and neurophysiological approaches.
  • Responsible for building a portfolio of academic scientists working to unravel the role of HTT in white matter pathology in HD.
  • Contribute to scientific strategy to achieve the goals of the clinical and translational neuroimaging research platform.
  • Work independently while leading individual study teams and directing the work of team members.
  • Keep abreast of new developments in the field, as well as the regulatory environment required to implement clinical studies.

Desired Qualifications, Skills and Experience

  • Ph.D. or MD in the field of nuclear medicine, neuroimaging, neurosciences with at least 5 years of direct experience in clinical research in pharma/biotech or academic settings.
  • The ideal candidate will have a background in both clinical experimental MRI and translational animal research. Previous expertise developed evaluating white matter pathophysiology would be preferred, while deeper specialization on advanced MRI methods, post processing and bioengineering is a plus.
  • Sophisticated understanding of neuroimaging pipeline analysis techniques, relevant neuroimaging software and data visualization tools.
  • Experience in machine learning, neuroimaging analytics and interpretation of statistical modeling would be an advantage.
  • Demonstrated ability to effectively contribute to clinical protocol design, data interpretation, and review and reporting of results from clinical studies.
  • Demonstrated knowledge of clinical trial components and support functions.
  • Knowledge of FDA, EMA/ICH regulations regarding clinical study conduct and Good Clinical Practice (GCP).
  • Excellent interpersonal skills, and both written and oral communication skills.
  • Flexible, well organized, with strong time management and multitasking skills.
  • Ability to work in a matrix organization and cross-functionally.
  • Background in neurodegenerative diseases, translational neuroscience and biomarker development is preferred.

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