Vice President Experimental Clinical Research

Vice President, Experimental (Clinical Research)

Job Location

The position will be based in Princeton, N.J. with occasional travel to New York City and Los Angeles.

Job Reports To

Chief Clinical Officer (CCO)

Job Description

CHDI is a privately-funded, not-for-profit biomedical research organization devoted to a single disease – Huntington’s disease (HD). Our mission is to develop drugs that will slow the progression of HD and provide meaningful clinical benefit to patients. CHDI is a “science first” organization; our foremost consideration is to do the best science as quickly and efficiently as possible.

CHDI’s clinical unit oversees a portfolio of clinical research projects aimed at understanding the natural progression and pathophysiological basis of HD, developing the best biomarkers and outcome measures for use in clinical trials, finding ways to expedite and improve the execution of clinical trials, paving relevant regulatory pathways, and working with external partners to support their clinical development plans. The clinical unit engages a diverse array of partners to develop this portfolio, including academic institutions, government agencies, contract research organizations (CROs), biotech and pharmaceutical companies and encompasses three interconnected teams; platform, partnering and experimental clinical research. The experimental clinical research team is responsible for CHDI-initiated studies and interventional trials, including a growing portfolio of experimental medicine and biomarker studies.

We seek an experienced physician scientist and effective manager to lead the experimental clinical research team within the clinical unit.

The VP Experimental (Clinical Research) will work on an interdisciplinary basis with internal CHDI colleagues (scientific, legal and financial) and a wide range of external collaborators (physicians, academic institutions, CROs, and biotech and pharmaceutical companies) on all aspects of CHDI’s research and development efforts. In particular, the VP Experimental (Clinical Research) will work closely with CHDI’s preclinical unit to design and implement studies that evaluate critical pre-clinical findings in human research participants.

Job Responsibilities

The VP Experimental (Clinical Research) will be expected to lead, manage and mentor the Science Directors and Program Managers on his or her team and work closely with other VPs and Science Directors on other clinical teams and in the preclinical unit to:

  • Define, in coordination with the CMO, the strategy for the experimental clinical research teams using his or her medical, scientific research and managerial expertise to decide on the best/feasible technical opportunities in the face of knowledge gaps
  • Implement the defined strategy of the experimental clinical research team
  • Contribute to the development of the strategies of the other clinical teams
  • Oversee the execution of experimental clinical research projects in compliance with the Foundation policies. This includes the overseeing the development, documentation and execution of clinical study and trial plans
  • Provide leadership, direction, and coaching to the Science Directors and Program Managers of the experimental clinical research team
  • Anticipate areas of risk, and plan and implement solutions to mitigate these risks in collaboration with CMO
  • Demonstrate a collegial, collaborative interpersonal style and an ability to implement inclusive approaches that foster engagement and achieves alignment across diverse constituencies
  • Establish and maintain strong relationships with key stakeholders and partners in external collaborative efforts (universities, government agencies, not-for-profit organizations, pharma/biotech companies)


The successful candidate will have:

  • An advanced degree (MD or MD/PhD) in a relevant field (eg, neurology or psychiatry)
  • Relevant postdoctoral experience a plus
  • 8+ years hands-on experience with early stages of drug development (phase I and II). Neurodegenerative diseases and/or movement disorders experience preferred
  • Experience with GCP/ICH guidelines and best practices in clinical research and development. Movement Disorders and Neurodegenerative diseases experiences preferred
  • Demonstrated leadership, managerial and communication skills, including mentoring others

The successful candidate will:

  • Be a team player possessing a sense of urgency to develop effective treatments for HD
  • Have the ability and interest to travel to engage external collaborators and colleagues

About CHDI Foundation, Inc.

CHDI is a private, not-for-profit research organization. We work with an international network of scientists to discover drugs that slow the progression of Huntington’s disease and provide meaningful clinical benefit to patients. We seek to accelerate scientific progress by serving as a collaborative enabler. We encourage and support cooperation and collaboration among HD researchers. Our strategy is to encourage researchers to develop practical ideas, useful research materials, and powerful technologies, often by providing financial support. Our activities extend from exploratory biology to the identification and validation of therapeutic targets, and from drug discovery and development to clinical studies and trials.

About CHDI Management, Inc.

CHDI Management, Inc. was established in 2002 to provide administrative and management services to CHDI Foundation, Inc.

About our Donors

CHDI’s activities focus solely on the identification and development of drugs that delay or slow Huntington’s disease. We are indebted to our donors, whose generosity and guidance have made possible this exclusive focus on science.

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